Novel PAP-targeted CAR-T therapy enhances antitumor efficacy through CoupledCAR approach

Novel PAP-targeted CAR-T therapy enhances antitumor efficacy through CoupledCAR approach

Background The challenges that remain in the treatment of solid tumors with chimeric antigen receptor (CAR)-T cells include limited solid tumor-specific targets and poor CAR-T cell expansion and function due to limited availability of solid tumor antigens outside the tumor microenvironment. Prostate...

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Main Authors: Wei Ding, Xi Huang, Zhiyuan Cao, Chengfei Pu, Xianyang Jiang, Xiaogang Shen, Zhao Wu, Lei Xiao, Beibei Jia, Guiting Han, Wensheng Wang, Zhipeng Huang, Victor X Lu, Le Tian
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/5/e011238.full
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