Among 69,178 UK Residents Ages 65+ Years, Frailty Associates Significantly With Lifestyle Behaviors and Depression: A Cross‐Sectional Study
ABSTRACT Background Frailty and depression are highly prevalent in older adults. However, the complex association of their interlinked factors, including lifestyle behaviors, remains unexplored in population‐based epidemiological studies. Aims This study aimed to evaluate the relationship between fr...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-03-01
|
| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.70593 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850207497194831872 |
|---|---|
| author | Jisu Kim Jonathan Kenyon Juan Lu Lana Sargent Youngdeok Kim |
| author_facet | Jisu Kim Jonathan Kenyon Juan Lu Lana Sargent Youngdeok Kim |
| author_sort | Jisu Kim |
| collection | DOAJ |
| description | ABSTRACT Background Frailty and depression are highly prevalent in older adults. However, the complex association of their interlinked factors, including lifestyle behaviors, remains unexplored in population‐based epidemiological studies. Aims This study aimed to evaluate the relationship between frailty and depression and to determine associated modifiable lifestyle risk factors for depression among older adults in the UK Biobank (UKB). Methods Data were obtained from 69,178 older adults (aged ≥ 65 yrs) in the baseline survey of the UKB. Frailty status was measured using the frailty phenotype criteria (range: 0–5). Participants were classified into frail (≥ 3), pre‐frail (1–2), and non‐frail (0) groups. The outcome of depression was defined by participants who had sought medical attention for nerves, anxiety, tension, or depression. Lifestyle behaviors included the self‐reported time spent in moderate‐to‐vigorous physical activity (MVPA), screen‐based sedentary behavior, and sleep. The association of interest is examined using multivariable logistic regression models. Results 29% of participants had depression, of which 7% and 45% were frail and pre‐frail, respectively. Significant correlations are observed between frailty and lifestyle behaviors (p's < 0.05). Frailty is significantly associated with increased odds of having depression (Frail: aOR = 1.87, 95% CI = 1.72, 2.04); Pre‐frail: aOR = 1.22, 95% CI = 1.18, 1.27), and sleep (7–8 h/d) is associated with lower odds of having depression (aOR = 0.81, 95% CI = 0.78, 0.84). Conclusion Frail and pre‐frail older adults have a higher likelihood of experiencing depression than their non‐frail counterparts. Meeting the recommended sleep duration (7–8 h/d) can be used as a modifiable behavioral strategy to manage or prevent depression. Further longitudinal studies are warranted to examine the time sequence in this relationship. |
| format | Article |
| id | doaj-art-1ca33a63727146b0a8dafd12930a41a3 |
| institution | OA Journals |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-1ca33a63727146b0a8dafd12930a41a32025-08-20T02:10:31ZengWileyHealth Science Reports2398-88352025-03-0183n/an/a10.1002/hsr2.70593Among 69,178 UK Residents Ages 65+ Years, Frailty Associates Significantly With Lifestyle Behaviors and Depression: A Cross‐Sectional StudyJisu Kim0Jonathan Kenyon1Juan Lu2Lana Sargent3Youngdeok Kim4Department of Kinesiology and Health Sciences Virginia Commonwealth University Richmond Virginia USADepartment of Kinesiology and Health Sciences Virginia Commonwealth University Richmond Virginia USADepartment of Epidemiology, School of Public Health Virginia Commonwealth University Richmond Virginia USADepartment of Adult Health and Nursing System, School of Nursing Virginia Commonwealth University Richmond Virginia USADepartment of Kinesiology and Health Sciences Virginia Commonwealth University Richmond Virginia USAABSTRACT Background Frailty and depression are highly prevalent in older adults. However, the complex association of their interlinked factors, including lifestyle behaviors, remains unexplored in population‐based epidemiological studies. Aims This study aimed to evaluate the relationship between frailty and depression and to determine associated modifiable lifestyle risk factors for depression among older adults in the UK Biobank (UKB). Methods Data were obtained from 69,178 older adults (aged ≥ 65 yrs) in the baseline survey of the UKB. Frailty status was measured using the frailty phenotype criteria (range: 0–5). Participants were classified into frail (≥ 3), pre‐frail (1–2), and non‐frail (0) groups. The outcome of depression was defined by participants who had sought medical attention for nerves, anxiety, tension, or depression. Lifestyle behaviors included the self‐reported time spent in moderate‐to‐vigorous physical activity (MVPA), screen‐based sedentary behavior, and sleep. The association of interest is examined using multivariable logistic regression models. Results 29% of participants had depression, of which 7% and 45% were frail and pre‐frail, respectively. Significant correlations are observed between frailty and lifestyle behaviors (p's < 0.05). Frailty is significantly associated with increased odds of having depression (Frail: aOR = 1.87, 95% CI = 1.72, 2.04); Pre‐frail: aOR = 1.22, 95% CI = 1.18, 1.27), and sleep (7–8 h/d) is associated with lower odds of having depression (aOR = 0.81, 95% CI = 0.78, 0.84). Conclusion Frail and pre‐frail older adults have a higher likelihood of experiencing depression than their non‐frail counterparts. Meeting the recommended sleep duration (7–8 h/d) can be used as a modifiable behavioral strategy to manage or prevent depression. Further longitudinal studies are warranted to examine the time sequence in this relationship.https://doi.org/10.1002/hsr2.70593depressionfrailtylifestyle behaviorssleep |
| spellingShingle | Jisu Kim Jonathan Kenyon Juan Lu Lana Sargent Youngdeok Kim Among 69,178 UK Residents Ages 65+ Years, Frailty Associates Significantly With Lifestyle Behaviors and Depression: A Cross‐Sectional Study Health Science Reports depression frailty lifestyle behaviors sleep |
| title | Among 69,178 UK Residents Ages 65+ Years, Frailty Associates Significantly With Lifestyle Behaviors and Depression: A Cross‐Sectional Study |
| title_full | Among 69,178 UK Residents Ages 65+ Years, Frailty Associates Significantly With Lifestyle Behaviors and Depression: A Cross‐Sectional Study |
| title_fullStr | Among 69,178 UK Residents Ages 65+ Years, Frailty Associates Significantly With Lifestyle Behaviors and Depression: A Cross‐Sectional Study |
| title_full_unstemmed | Among 69,178 UK Residents Ages 65+ Years, Frailty Associates Significantly With Lifestyle Behaviors and Depression: A Cross‐Sectional Study |
| title_short | Among 69,178 UK Residents Ages 65+ Years, Frailty Associates Significantly With Lifestyle Behaviors and Depression: A Cross‐Sectional Study |
| title_sort | among 69 178 uk residents ages 65 years frailty associates significantly with lifestyle behaviors and depression a cross sectional study |
| topic | depression frailty lifestyle behaviors sleep |
| url | https://doi.org/10.1002/hsr2.70593 |
| work_keys_str_mv | AT jisukim among69178ukresidentsages65yearsfrailtyassociatessignificantlywithlifestylebehaviorsanddepressionacrosssectionalstudy AT jonathankenyon among69178ukresidentsages65yearsfrailtyassociatessignificantlywithlifestylebehaviorsanddepressionacrosssectionalstudy AT juanlu among69178ukresidentsages65yearsfrailtyassociatessignificantlywithlifestylebehaviorsanddepressionacrosssectionalstudy AT lanasargent among69178ukresidentsages65yearsfrailtyassociatessignificantlywithlifestylebehaviorsanddepressionacrosssectionalstudy AT youngdeokkim among69178ukresidentsages65yearsfrailtyassociatessignificantlywithlifestylebehaviorsanddepressionacrosssectionalstudy |