Exploration of choroidal vascular changes in juveniles with different degrees of myopia: The application of swept-source optical coherence tomography angiography
Objective: To investigate the vascular characteristic changes in the macular retina and choriocapillaris, as well as the choroidal vascularization of eyes with different degrees of myopia in juveniles using Swept-source Optical Coherence Tomography (SS-OCT), aiming to understand the pathophysiologic...
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Elsevier
2025-08-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025002066 |
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| author | Linbo He Qing Wang Ziyang Li Libing Song Bo Liu Yuli Yang |
| author_facet | Linbo He Qing Wang Ziyang Li Libing Song Bo Liu Yuli Yang |
| author_sort | Linbo He |
| collection | DOAJ |
| description | Objective: To investigate the vascular characteristic changes in the macular retina and choriocapillaris, as well as the choroidal vascularization of eyes with different degrees of myopia in juveniles using Swept-source Optical Coherence Tomography (SS-OCT), aiming to understand the pathophysiological characteristics of myopic eyes further. Methods: We conducted a retrospective case-control study involving 103 patients (198 eyes) aged 6–17 years who had undergone SS-OCT examination. Based on equivalent spherical power, they were divided into four groups: emmetropia group, low myopia group, moderate myopia group, and high myopia group. The density of superficial capillary plexuses (SCP), choriocapillaris (CC), choroid vessel (CV)layers, and subfoveal choroidal thickness (SFCT) in the macular area were measured using SS-OCT. Multivariate regression analysis was employed to determine the ocular and demographic factors associated with retinal and choroidal blood flow indicators. Results: In the temporal parafoveal area, the superficial capillary plexus (SCP) density was significantly lower in the moderate myopia group compared to the low myopia group (47.27 ± 2.21 vs. 48.51 ± 1.8, p = 0.002). Conversely, subfoveal choroidal vessel (CV) density was substantially higher in highly myopic eyes than in emmetropic eyes (56.98± 3.65 vs. 53.70 ± 4.31, p = 0.023). The multiple linear regression analysis showed that in the area under the fovea, thinner choroidal thickness is associated with higher choroidal vessel density. Specifically, as choroidal thickness decreases, the density of choroidal vessels increases (p = 0.024). Conclusions: For juveniles, with the progression of myopia, the density of retinal superficial blood vessels and choroidal capillaries remains at a relatively stable level, while the choroidal vessel density under the fovea gradually increases. The main cause of changes in choroidal vessel density is the thickness of choroid under the fovea. |
| format | Article |
| id | doaj-art-1ca283dc786b41a5a8d4eb5074da2d5e |
| institution | DOAJ |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
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| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-1ca283dc786b41a5a8d4eb5074da2d5e2025-08-20T03:02:07ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-08-015410467410.1016/j.pdpdt.2025.104674Exploration of choroidal vascular changes in juveniles with different degrees of myopia: The application of swept-source optical coherence tomography angiographyLinbo He0Qing Wang1Ziyang Li2Libing Song3Bo Liu4Yuli Yang5Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, PR China; Key Lab of Visual Damage and Regeneration, Chongqing, PR ChinaSouthwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, PR China; Key Lab of Visual Damage and Regeneration, Chongqing, PR ChinaSouthwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, PR China; Key Lab of Visual Damage and Regeneration, Chongqing, PR ChinaSouthwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, PR China; Key Lab of Visual Damage and Regeneration, Chongqing, PR ChinaSouthwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, PR China; Key Lab of Visual Damage and Regeneration, Chongqing, PR ChinaSouthwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, PR China; Key Lab of Visual Damage and Regeneration, Chongqing, PR ChinaObjective: To investigate the vascular characteristic changes in the macular retina and choriocapillaris, as well as the choroidal vascularization of eyes with different degrees of myopia in juveniles using Swept-source Optical Coherence Tomography (SS-OCT), aiming to understand the pathophysiological characteristics of myopic eyes further. Methods: We conducted a retrospective case-control study involving 103 patients (198 eyes) aged 6–17 years who had undergone SS-OCT examination. Based on equivalent spherical power, they were divided into four groups: emmetropia group, low myopia group, moderate myopia group, and high myopia group. The density of superficial capillary plexuses (SCP), choriocapillaris (CC), choroid vessel (CV)layers, and subfoveal choroidal thickness (SFCT) in the macular area were measured using SS-OCT. Multivariate regression analysis was employed to determine the ocular and demographic factors associated with retinal and choroidal blood flow indicators. Results: In the temporal parafoveal area, the superficial capillary plexus (SCP) density was significantly lower in the moderate myopia group compared to the low myopia group (47.27 ± 2.21 vs. 48.51 ± 1.8, p = 0.002). Conversely, subfoveal choroidal vessel (CV) density was substantially higher in highly myopic eyes than in emmetropic eyes (56.98± 3.65 vs. 53.70 ± 4.31, p = 0.023). The multiple linear regression analysis showed that in the area under the fovea, thinner choroidal thickness is associated with higher choroidal vessel density. Specifically, as choroidal thickness decreases, the density of choroidal vessels increases (p = 0.024). Conclusions: For juveniles, with the progression of myopia, the density of retinal superficial blood vessels and choroidal capillaries remains at a relatively stable level, while the choroidal vessel density under the fovea gradually increases. The main cause of changes in choroidal vessel density is the thickness of choroid under the fovea.http://www.sciencedirect.com/science/article/pii/S1572100025002066SS-OCTOCTAMyopiaChoroidal bloodSwept-source Optical Coherence Tomography |
| spellingShingle | Linbo He Qing Wang Ziyang Li Libing Song Bo Liu Yuli Yang Exploration of choroidal vascular changes in juveniles with different degrees of myopia: The application of swept-source optical coherence tomography angiography Photodiagnosis and Photodynamic Therapy SS-OCT OCTA Myopia Choroidal blood Swept-source Optical Coherence Tomography |
| title | Exploration of choroidal vascular changes in juveniles with different degrees of myopia: The application of swept-source optical coherence tomography angiography |
| title_full | Exploration of choroidal vascular changes in juveniles with different degrees of myopia: The application of swept-source optical coherence tomography angiography |
| title_fullStr | Exploration of choroidal vascular changes in juveniles with different degrees of myopia: The application of swept-source optical coherence tomography angiography |
| title_full_unstemmed | Exploration of choroidal vascular changes in juveniles with different degrees of myopia: The application of swept-source optical coherence tomography angiography |
| title_short | Exploration of choroidal vascular changes in juveniles with different degrees of myopia: The application of swept-source optical coherence tomography angiography |
| title_sort | exploration of choroidal vascular changes in juveniles with different degrees of myopia the application of swept source optical coherence tomography angiography |
| topic | SS-OCT OCTA Myopia Choroidal blood Swept-source Optical Coherence Tomography |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025002066 |
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