Altered drug metabolism and increased susceptibility to fatty liver disease in a mouse model of myotonic dystrophy

Abstract Myotonic Dystrophy type 1 (DM1), a highly prevalent form of muscular dystrophy, is caused by (CTG)n repeat expansion in the DMPK gene. Much of DM1 research has focused on the effects within the muscle and neurological tissues; however, DM1 patients also suffer from various metabolic and liv...

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Bibliographic Details
Main Authors: Zachary Dewald, Oluwafolajimi Adesanya, Haneui Bae, Andrew Gupta, Jessica M. Derham, Ullas V. Chembazhi, Auinash Kalsotra
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53378-z
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