Decreased expression of insulin-degrading enzyme increases gluconeogenesis and glucose production in cultured hepatocytes administered with glucagon

Decreased expression of insulin-degrading enzyme increases gluconeogenesis and glucose production in cultured hepatocytes administered with glucagon

Abstract Insulin-degrading enzyme (IDE) is a protein with proteolytic and non-proteolytic functions that regulates glucose homeostasis. In the fasted state, glucagon regulates glycemia through induction of hepatic gluconeogenesis. The rate of hepatic gluconeogenesis is elevated in subjects with type...

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Main Authors: Carlos M. González-Casimiro, Patricia Cámara-Torres, Beatriz Merino, Alma M. Astudillo, Miguel A. de la Fuente, Cristina M. Ramírez, Andrés Alonso, Irene Cózar-Castellano, Germán Perdomo
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Glucagon
Gluconeogenesis
Hepatocytes
Insulin-degrading enzyme
Online Access:https://doi.org/10.1038/s41598-025-03790-2
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