Efficacy of Endovascular Glue Embolization in Treating Ruptured Intracranial Mycotic Aneurysms: A Single Center Experience
Purpose Intracranial mycotic aneurysms (IMAs), rare and often life-threatening, result from arterial wall infections typically caused by bacteria such as Staphylococcus and Streptococcus. The standard treatment for ruptured aneurysms is not well-defined and often individualized. This study investiga...
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Korean Society of Interventional Neuroradiology
2024-11-01
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| Series: | Neurointervention |
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| Online Access: | http://neurointervention.org/upload/pdf/neuroint-2024-00290.pdf |
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| author | Sukalyan Purkayastha Rajinder Kumar Dinesh Verma Deepak Dhurvey Nitin Kumar Surajit Jana |
| author_facet | Sukalyan Purkayastha Rajinder Kumar Dinesh Verma Deepak Dhurvey Nitin Kumar Surajit Jana |
| author_sort | Sukalyan Purkayastha |
| collection | DOAJ |
| description | Purpose Intracranial mycotic aneurysms (IMAs), rare and often life-threatening, result from arterial wall infections typically caused by bacteria such as Staphylococcus and Streptococcus. The standard treatment for ruptured aneurysms is not well-defined and often individualized. This study investigates the efficacy of endovascular glue embolization in managing ruptured IMAs, based on our center’s experience. Materials and Methods A retrospective analysis was conducted for ruptured IMAs treated with glue embolization between January 2016 and December 2023. The procedure involved aneurysm sac and parent vessel occlusion with glue delivery. Data included patient demographics, clinical presentations, and neuroimaging. Clinical outcomes were assessed using the modified Rankin scale (mRS) at 3 months, and angiographic follow-up was conducted at 6 months. Results The study included 28 patients, predominantly male (64.3%), with a mean age of 48 years. Headache was the primary symptom in 92.9% of cases, and positive blood/cerebro spinal fluid cultures were found in 82.14% of cases. All aneurysms were located in the distal circulation, primarily in the anterior circulation system. Glue embolization was successfully performed in all cases, achieving complete aneurysm sac and parent vessel obliteration. Follow-up at 3 months indicated mRS scores of 0 or 1 in 96.5% of cases. Six-month angiographic follow-up showed no aneurysm regrowth or new formations. Conclusion Endovascular glue embolization demonstrated high efficacy and safety in treating ruptured IMAs, with a 100% obliteration rate and favorable clinical outcomes in this single-center experience. Despite limitations such as its retrospective design and small sample size, the study supports glue embolization as a viable, less invasive alternative to traditional surgery. Further comparative studies are needed to confirm these findings and refine treatment approaches. |
| format | Article |
| id | doaj-art-1ca14b2206c2436eb2ba8b2cf66be55b |
| institution | OA Journals |
| issn | 2093-9043 2233-6273 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Korean Society of Interventional Neuroradiology |
| record_format | Article |
| series | Neurointervention |
| spelling | doaj-art-1ca14b2206c2436eb2ba8b2cf66be55b2025-08-20T02:12:14ZengKorean Society of Interventional NeuroradiologyNeurointervention2093-90432233-62732024-11-0119315616110.5469/neuroint.2024.00290442Efficacy of Endovascular Glue Embolization in Treating Ruptured Intracranial Mycotic Aneurysms: A Single Center ExperienceSukalyan Purkayastha0Rajinder KumarDinesh Verma1Deepak Dhurvey2Nitin Kumar3Surajit Jana4 Department of Neurointervention, Institute of Neuroscience, Kolkata, India Department of Neurointervention, Institute of Neuroscience, Kolkata, India Department of Neurointervention, Institute of Neuroscience, Kolkata, India Department of Neurointervention, Institute of Neuroscience, Kolkata, India Department of Neurointervention, Institute of Neuroscience, Kolkata, IndiaPurpose Intracranial mycotic aneurysms (IMAs), rare and often life-threatening, result from arterial wall infections typically caused by bacteria such as Staphylococcus and Streptococcus. The standard treatment for ruptured aneurysms is not well-defined and often individualized. This study investigates the efficacy of endovascular glue embolization in managing ruptured IMAs, based on our center’s experience. Materials and Methods A retrospective analysis was conducted for ruptured IMAs treated with glue embolization between January 2016 and December 2023. The procedure involved aneurysm sac and parent vessel occlusion with glue delivery. Data included patient demographics, clinical presentations, and neuroimaging. Clinical outcomes were assessed using the modified Rankin scale (mRS) at 3 months, and angiographic follow-up was conducted at 6 months. Results The study included 28 patients, predominantly male (64.3%), with a mean age of 48 years. Headache was the primary symptom in 92.9% of cases, and positive blood/cerebro spinal fluid cultures were found in 82.14% of cases. All aneurysms were located in the distal circulation, primarily in the anterior circulation system. Glue embolization was successfully performed in all cases, achieving complete aneurysm sac and parent vessel obliteration. Follow-up at 3 months indicated mRS scores of 0 or 1 in 96.5% of cases. Six-month angiographic follow-up showed no aneurysm regrowth or new formations. Conclusion Endovascular glue embolization demonstrated high efficacy and safety in treating ruptured IMAs, with a 100% obliteration rate and favorable clinical outcomes in this single-center experience. Despite limitations such as its retrospective design and small sample size, the study supports glue embolization as a viable, less invasive alternative to traditional surgery. Further comparative studies are needed to confirm these findings and refine treatment approaches.http://neurointervention.org/upload/pdf/neuroint-2024-00290.pdfintracranial mycotic aneurysmembolizationoutcome assessment |
| spellingShingle | Sukalyan Purkayastha Rajinder Kumar Dinesh Verma Deepak Dhurvey Nitin Kumar Surajit Jana Efficacy of Endovascular Glue Embolization in Treating Ruptured Intracranial Mycotic Aneurysms: A Single Center Experience Neurointervention intracranial mycotic aneurysm embolization outcome assessment |
| title | Efficacy of Endovascular Glue Embolization in Treating Ruptured Intracranial Mycotic Aneurysms: A Single Center Experience |
| title_full | Efficacy of Endovascular Glue Embolization in Treating Ruptured Intracranial Mycotic Aneurysms: A Single Center Experience |
| title_fullStr | Efficacy of Endovascular Glue Embolization in Treating Ruptured Intracranial Mycotic Aneurysms: A Single Center Experience |
| title_full_unstemmed | Efficacy of Endovascular Glue Embolization in Treating Ruptured Intracranial Mycotic Aneurysms: A Single Center Experience |
| title_short | Efficacy of Endovascular Glue Embolization in Treating Ruptured Intracranial Mycotic Aneurysms: A Single Center Experience |
| title_sort | efficacy of endovascular glue embolization in treating ruptured intracranial mycotic aneurysms a single center experience |
| topic | intracranial mycotic aneurysm embolization outcome assessment |
| url | http://neurointervention.org/upload/pdf/neuroint-2024-00290.pdf |
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