Protein lactylation in kidney diseases
Post-translational modifications (PTMs) regulate protein function and structure through covalent modifications, participating in various physiological and pathological processes. Lysine lactylation is an emerging PTM discovered in recent years, which regulates gene expression, metabolism, and cell s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1533175/full |
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| author | Yelei Xu Xinming Li Xinming Li Zhiguo Mao Cheng Xue |
| author_facet | Yelei Xu Xinming Li Xinming Li Zhiguo Mao Cheng Xue |
| author_sort | Yelei Xu |
| collection | DOAJ |
| description | Post-translational modifications (PTMs) regulate protein function and structure through covalent modifications, participating in various physiological and pathological processes. Lysine lactylation is an emerging PTM discovered in recent years, which regulates gene expression, metabolism, and cell signaling by adding a lactyl group to lysine residues. As a by-product of glycolysis, lactate not only influences cellular metabolism but also contributes to the development and progression of kidney diseases through lactylation. This review focuses on the discovery and regulatory mechanisms of lysine lactylation, particularly its role in kidney diseases such as acute kidney injury, chronic kidney disease, and diabetic kidney disease. Lactylation influences the metabolic state, inflammatory response, and fibrosis of renal cells by modulating protein function and key gene transcription. With continued research, lactylation is expected to become a novel target for understanding the metabolic-epigenetic regulation of kidney diseases and could offer new strategies for treatment. |
| format | Article |
| id | doaj-art-1c9e5808c1d44eb9932003bcbc11cdad |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-1c9e5808c1d44eb9932003bcbc11cdad2025-08-20T03:35:53ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-08-011310.3389/fcell.2025.15331751533175Protein lactylation in kidney diseasesYelei Xu0Xinming Li1Xinming Li2Zhiguo Mao3Cheng Xue4Naval Medical University (Second Military Medical University), Shanghai, ChinaNaval Medical University (Second Military Medical University), Shanghai, ChinaDivision of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai, ChinaDivision of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai, ChinaDivision of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai, ChinaPost-translational modifications (PTMs) regulate protein function and structure through covalent modifications, participating in various physiological and pathological processes. Lysine lactylation is an emerging PTM discovered in recent years, which regulates gene expression, metabolism, and cell signaling by adding a lactyl group to lysine residues. As a by-product of glycolysis, lactate not only influences cellular metabolism but also contributes to the development and progression of kidney diseases through lactylation. This review focuses on the discovery and regulatory mechanisms of lysine lactylation, particularly its role in kidney diseases such as acute kidney injury, chronic kidney disease, and diabetic kidney disease. Lactylation influences the metabolic state, inflammatory response, and fibrosis of renal cells by modulating protein function and key gene transcription. With continued research, lactylation is expected to become a novel target for understanding the metabolic-epigenetic regulation of kidney diseases and could offer new strategies for treatment.https://www.frontiersin.org/articles/10.3389/fcell.2025.1533175/fulllactatelactylationpost-translational modificationchronic kidney diseaseacute kidney injurydiabetic kidney disease |
| spellingShingle | Yelei Xu Xinming Li Xinming Li Zhiguo Mao Cheng Xue Protein lactylation in kidney diseases Frontiers in Cell and Developmental Biology lactate lactylation post-translational modification chronic kidney disease acute kidney injury diabetic kidney disease |
| title | Protein lactylation in kidney diseases |
| title_full | Protein lactylation in kidney diseases |
| title_fullStr | Protein lactylation in kidney diseases |
| title_full_unstemmed | Protein lactylation in kidney diseases |
| title_short | Protein lactylation in kidney diseases |
| title_sort | protein lactylation in kidney diseases |
| topic | lactate lactylation post-translational modification chronic kidney disease acute kidney injury diabetic kidney disease |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1533175/full |
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