Placebo and nocebo effects in the neurological practice
Knowledge of placebo and nocebo effects is essential to identify their influence on the results in clinical practice and clinical trials, and thereby properly interpret their results. It is known that the gold standard of clinical trials re...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2015-01-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000100058&lng=en&tlng=en |
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| _version_ | 1849307897295536128 |
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| author | Caroline Bittar Osvaldo J.M. Nascimento |
| author_facet | Caroline Bittar Osvaldo J.M. Nascimento |
| author_sort | Caroline Bittar |
| collection | DOAJ |
| description | Knowledge of placebo and nocebo effects is essential to identify their influence on the results in clinical practice and clinical trials, and thereby properly interpret their results. It is known that the gold standard of clinical trials research is the double-blind, placebo-controlled, randomized clinical study. The objective of this review is to distinguish specific from non-specific effects, so that the presence of positive effects in the group that received placebo (placebo effect) and the presence of adverse effects in the group receiving placebo (nocebo effect) lead to confounding in interpreting the results. Placebo and nocebo effects have been considered in neurological diseases such as depression, pain, headache, multiple sclerosis, epilepsy. As placebo and nocebo effects are also present in clinical practice, the purpose of this review is to draw attention to their influence on neurological practice, calling attention to the development of measures that can minimize them. |
| format | Article |
| id | doaj-art-1c98684b01aa42adb5f2d6fa85f60cb6 |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-1c98684b01aa42adb5f2d6fa85f60cb62025-08-20T03:54:37ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272015-01-01731586310.1590/0004-282X20140180S0004-282X2015000100058Placebo and nocebo effects in the neurological practiceCaroline BittarOsvaldo J.M. NascimentoKnowledge of placebo and nocebo effects is essential to identify their influence on the results in clinical practice and clinical trials, and thereby properly interpret their results. It is known that the gold standard of clinical trials research is the double-blind, placebo-controlled, randomized clinical study. The objective of this review is to distinguish specific from non-specific effects, so that the presence of positive effects in the group that received placebo (placebo effect) and the presence of adverse effects in the group receiving placebo (nocebo effect) lead to confounding in interpreting the results. Placebo and nocebo effects have been considered in neurological diseases such as depression, pain, headache, multiple sclerosis, epilepsy. As placebo and nocebo effects are also present in clinical practice, the purpose of this review is to draw attention to their influence on neurological practice, calling attention to the development of measures that can minimize them.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000100058&lng=en&tlng=enplacebonocebodor neuropáticacefaleiaesclerose múltiplaepilepsiaensaios clínicos |
| spellingShingle | Caroline Bittar Osvaldo J.M. Nascimento Placebo and nocebo effects in the neurological practice Arquivos de Neuro-Psiquiatria placebo nocebo dor neuropática cefaleia esclerose múltipla epilepsia ensaios clínicos |
| title | Placebo and nocebo effects in the neurological practice |
| title_full | Placebo and nocebo effects in the neurological practice |
| title_fullStr | Placebo and nocebo effects in the neurological practice |
| title_full_unstemmed | Placebo and nocebo effects in the neurological practice |
| title_short | Placebo and nocebo effects in the neurological practice |
| title_sort | placebo and nocebo effects in the neurological practice |
| topic | placebo nocebo dor neuropática cefaleia esclerose múltipla epilepsia ensaios clínicos |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000100058&lng=en&tlng=en |
| work_keys_str_mv | AT carolinebittar placeboandnoceboeffectsintheneurologicalpractice AT osvaldojmnascimento placeboandnoceboeffectsintheneurologicalpractice |