Mex3a-dependent post-transcriptional silencing ensures olfactory receptor diversity and axon guidance specificity

Mex3a-dependent post-transcriptional silencing ensures olfactory receptor diversity and axon guidance specificity

Summary: Olfactory sensory neurons (OSNs) use olfactory receptor (OR)-specific patterns of endoplasmic reticulum (ER) stress to transform OR sequence identity into axon guidance precision. However, during neuronal differentiation, OSNs transiently co-express random combinations of OR genes, which co...

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Main Authors: Rachel Duffié, Hani Shayya, Martín Escamilla del Arenal, Miao Wang, Jerome Kahiapo, Aileen Ugurbil, Abdurrahman Keskin, Fiona Clowney, Elizaveta V. Bashkirova, Ariel D. Pourmorady, Ira Schieren, Humberto Ibarra Avila, Luke E. Berchowitz, Francisco M. Barriga, Eduard Batlle, Marko Jovanovic, Stavros Lomvardas
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007508
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