The Effects of TLR Activation on T-Cell Development and Differentiation
Invading pathogens have unique molecular signatures that are recognized by Toll-like receptors (TLRs) resulting in either activation of antigen-presenting cells (APCs) and/or costimulation of T cells inducing both innate and adaptive immunity. TLRs are also involved in T-cell development and can rep...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/836485 |
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| author | Bo Jin Tao Sun Xiao-Hong Yu Ying-Xiang Yang Anthony E. T. Yeo |
| author_facet | Bo Jin Tao Sun Xiao-Hong Yu Ying-Xiang Yang Anthony E. T. Yeo |
| author_sort | Bo Jin |
| collection | DOAJ |
| description | Invading pathogens have unique molecular signatures that are recognized by Toll-like receptors (TLRs) resulting in either activation of antigen-presenting cells (APCs) and/or costimulation of T cells inducing both innate and adaptive immunity. TLRs are also involved in T-cell development and can reprogram Treg cells to become helper cells. T cells consist of various subsets, that is, Th1, Th2, Th17, T follicular helper (Tfh), cytotoxic T lymphocytes (CTLs), regulatory T cells (Treg) and these originate from thymic progenitor thymocytes. T-cell receptor (TCR) activation in distinct T-cell subsets with different TLRs results in differing outcomes, for example, activation of TLR4 expressed in T cells promotes suppressive function of regulatory T cells (Treg), while activation of TLR6 expressed in T cells abrogates Treg function. The current state of knowledge of regarding TLR-mediated T-cell development and differentiation is reviewed. |
| format | Article |
| id | doaj-art-1c8e76edbec84fda967cba1ec07c71bb |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-1c8e76edbec84fda967cba1ec07c71bb2025-02-03T01:24:21ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/836485836485The Effects of TLR Activation on T-Cell Development and DifferentiationBo Jin0Tao Sun1Xiao-Hong Yu2Ying-Xiang Yang3Anthony E. T. Yeo4Department of Gastroenterology, The 309th Hospital of The People's Liberation Army, Beijing 100091, ChinaDepartment of Infectious Diseases, Naval General Hospital, Beijing 100048, ChinaDepartment of Infectious Diseases, Naval General Hospital, Beijing 100048, ChinaDepartment of Infectious Diseases, Naval General Hospital, Beijing 100048, ChinaSavient Pharmaceuticals, East Brunswick, NJ 08116, USAInvading pathogens have unique molecular signatures that are recognized by Toll-like receptors (TLRs) resulting in either activation of antigen-presenting cells (APCs) and/or costimulation of T cells inducing both innate and adaptive immunity. TLRs are also involved in T-cell development and can reprogram Treg cells to become helper cells. T cells consist of various subsets, that is, Th1, Th2, Th17, T follicular helper (Tfh), cytotoxic T lymphocytes (CTLs), regulatory T cells (Treg) and these originate from thymic progenitor thymocytes. T-cell receptor (TCR) activation in distinct T-cell subsets with different TLRs results in differing outcomes, for example, activation of TLR4 expressed in T cells promotes suppressive function of regulatory T cells (Treg), while activation of TLR6 expressed in T cells abrogates Treg function. The current state of knowledge of regarding TLR-mediated T-cell development and differentiation is reviewed.http://dx.doi.org/10.1155/2012/836485 |
| spellingShingle | Bo Jin Tao Sun Xiao-Hong Yu Ying-Xiang Yang Anthony E. T. Yeo The Effects of TLR Activation on T-Cell Development and Differentiation Clinical and Developmental Immunology |
| title | The Effects of TLR Activation on T-Cell Development and Differentiation |
| title_full | The Effects of TLR Activation on T-Cell Development and Differentiation |
| title_fullStr | The Effects of TLR Activation on T-Cell Development and Differentiation |
| title_full_unstemmed | The Effects of TLR Activation on T-Cell Development and Differentiation |
| title_short | The Effects of TLR Activation on T-Cell Development and Differentiation |
| title_sort | effects of tlr activation on t cell development and differentiation |
| url | http://dx.doi.org/10.1155/2012/836485 |
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