Comprehensive neurosurgical and visceral surgical therapy of retroperitoneal nerve tumors: a descriptive and retrospective analysis
Abstract Nerve tumors in the retroperitoneal space are a rarity. Radical surgery according to soft tissue tumors can lead to persistent pain and neurological deficits. This study aims to evaluate clinical outcomes of patients treated by a visceral- / neurosurgical approach. 33 patients with a retrop...
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BMC
2024-10-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-024-03557-5 |
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| author | Martin Petkov Marko Kornmann Ute Marlies Bäzner Lena Minzenmay Andrej Pala Maria Teresa Pedro Christian Rainer Wirtz Gregor Antoniadis |
| author_facet | Martin Petkov Marko Kornmann Ute Marlies Bäzner Lena Minzenmay Andrej Pala Maria Teresa Pedro Christian Rainer Wirtz Gregor Antoniadis |
| author_sort | Martin Petkov |
| collection | DOAJ |
| description | Abstract Nerve tumors in the retroperitoneal space are a rarity. Radical surgery according to soft tissue tumors can lead to persistent pain and neurological deficits. This study aims to evaluate clinical outcomes of patients treated by a visceral- / neurosurgical approach. 33 patients with a retroperitoneal nerve tumor underwent surgery between 01/2002 and 12/2022 at our department. A visceral surgeon provided access to the retroperitoneal space, followed by micro-neurosurgical tumor preparation under neuromonitoring. Clinical examination and MRI were performed 12 weeks after surgery and further 3 months (WHO grade > 1) or 12 months (WHO grade 1). Further examinations were based on MRI findings and residual symptoms with median follow-up time of 24 months. One patient was treated for two distinct masses resulting in a total of 34 histological findings. Schwannomas (n = 15; 44.1%) and neurofibromas (n = 10; 29.4%) were the most common tumors. Long-term improvements were noted in radicular pain (15/18 patients; 83.3%), motor deficits (7/16 patients; 43.8%), abdominal discomfort and pain (5/7 patients; 71.4%). Recurrences were observed in 3/33 (9,1%) patients. This study represents the largest series of retroperitoneal BPNSTs treated with microsurgical techniques. Prospective multicenter studies are warranted to establish standardized treatment guidelines. |
| format | Article |
| id | doaj-art-1c8e69fa85074e8a8fae90b903bd3143 |
| institution | OA Journals |
| issn | 1477-7819 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-1c8e69fa85074e8a8fae90b903bd31432025-08-20T02:11:22ZengBMCWorld Journal of Surgical Oncology1477-78192024-10-0122111010.1186/s12957-024-03557-5Comprehensive neurosurgical and visceral surgical therapy of retroperitoneal nerve tumors: a descriptive and retrospective analysisMartin Petkov0Marko Kornmann1Ute Marlies Bäzner2Lena Minzenmay3Andrej Pala4Maria Teresa Pedro5Christian Rainer Wirtz6Gregor Antoniadis7Bezirkskrankenhaus Günzburg, Peripheral Nerve Surgery Unit, University of UlmDepartment of General and Visceral Surgery, University of UlmBezirkskrankenhaus Günzburg, Peripheral Nerve Surgery Unit, University of UlmBezirkskrankenhaus Günzburg, Peripheral Nerve Surgery Unit, University of UlmBezirkskrankenhaus Günzburg, Peripheral Nerve Surgery Unit, University of UlmBezirkskrankenhaus Günzburg, Peripheral Nerve Surgery Unit, University of UlmDepartment of Neurosurgery, University of UlmBezirkskrankenhaus Günzburg, Peripheral Nerve Surgery Unit, University of UlmAbstract Nerve tumors in the retroperitoneal space are a rarity. Radical surgery according to soft tissue tumors can lead to persistent pain and neurological deficits. This study aims to evaluate clinical outcomes of patients treated by a visceral- / neurosurgical approach. 33 patients with a retroperitoneal nerve tumor underwent surgery between 01/2002 and 12/2022 at our department. A visceral surgeon provided access to the retroperitoneal space, followed by micro-neurosurgical tumor preparation under neuromonitoring. Clinical examination and MRI were performed 12 weeks after surgery and further 3 months (WHO grade > 1) or 12 months (WHO grade 1). Further examinations were based on MRI findings and residual symptoms with median follow-up time of 24 months. One patient was treated for two distinct masses resulting in a total of 34 histological findings. Schwannomas (n = 15; 44.1%) and neurofibromas (n = 10; 29.4%) were the most common tumors. Long-term improvements were noted in radicular pain (15/18 patients; 83.3%), motor deficits (7/16 patients; 43.8%), abdominal discomfort and pain (5/7 patients; 71.4%). Recurrences were observed in 3/33 (9,1%) patients. This study represents the largest series of retroperitoneal BPNSTs treated with microsurgical techniques. Prospective multicenter studies are warranted to establish standardized treatment guidelines.https://doi.org/10.1186/s12957-024-03557-5BPNSTMPNSTNerveTumorRetroperitoneumVisceral |
| spellingShingle | Martin Petkov Marko Kornmann Ute Marlies Bäzner Lena Minzenmay Andrej Pala Maria Teresa Pedro Christian Rainer Wirtz Gregor Antoniadis Comprehensive neurosurgical and visceral surgical therapy of retroperitoneal nerve tumors: a descriptive and retrospective analysis World Journal of Surgical Oncology BPNST MPNST Nerve Tumor Retroperitoneum Visceral |
| title | Comprehensive neurosurgical and visceral surgical therapy of retroperitoneal nerve tumors: a descriptive and retrospective analysis |
| title_full | Comprehensive neurosurgical and visceral surgical therapy of retroperitoneal nerve tumors: a descriptive and retrospective analysis |
| title_fullStr | Comprehensive neurosurgical and visceral surgical therapy of retroperitoneal nerve tumors: a descriptive and retrospective analysis |
| title_full_unstemmed | Comprehensive neurosurgical and visceral surgical therapy of retroperitoneal nerve tumors: a descriptive and retrospective analysis |
| title_short | Comprehensive neurosurgical and visceral surgical therapy of retroperitoneal nerve tumors: a descriptive and retrospective analysis |
| title_sort | comprehensive neurosurgical and visceral surgical therapy of retroperitoneal nerve tumors a descriptive and retrospective analysis |
| topic | BPNST MPNST Nerve Tumor Retroperitoneum Visceral |
| url | https://doi.org/10.1186/s12957-024-03557-5 |
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