Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics

Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics

Abstract The global race against antimicrobial resistance requires novel antimicrobials that are not only effective in killing specific bacteria, but also minimize the emergence of new resistances. Recently, CRISPR/Cas-based antimicrobials were proposed to address killing specificity with encouragin...

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Bibliographic Details
Main Authors: Angelica Frusteri Chiacchiera, Michela Casanova, Massimo Bellato, Aurora Piazza, Roberta Migliavacca, Gregory Batt, Paolo Magni, Lorenzo Pasotti
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Antimicrobial resistance
Antibiotic re-sensitization
CRISPR array
Escherichia coli clinical isolates
bla NDM-type
bla ctx−M-type
Online Access:https://doi.org/10.1038/s41598-024-81989-5
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