Metabolic dependency mapping identifies Peroxiredoxin 1 as a driver of resistance to ATM inhibition

Metabolic dependency mapping identifies Peroxiredoxin 1 as a driver of resistance to ATM inhibition

Metabolic pathways fuel tumor progression and resistance to stress conditions including chemotherapeutic drugs, such as DNA damage response (DDR) inhibitors. Yet, significant gaps persist in how metabolic pathways confer resistance to DDR inhibition in cancer cells. Here, we employed a metabolism-fo...

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Main Authors: Haojian Li, Takashi Furusawa, Renzo Cavero, Yunjie Xiao, Raj Chari, Xiaolin Wu, David Sun, Oliver Hartmann, Anjali Dhall, Ronald Holewinski, Thorkell Andresson, Baktiar Karim, Marina Villamor-Payà, Devorah Gallardo, Chi-Ping Day, Lipika R. Pal, Nishanth Ulhas Nair, Eytan Ruppin, Mirit I. Aladjem, Yves Pommier, Markus E. Diefenbacher, Jung Mi Lim, Rodney L. Levine, Travis H. Stracker, Urbain Weyemi
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Redox Biology
Subjects:
ATM kinase
Peroxiredoxin 1
Disulfide stress
p53 activation
RPL32 redox modification
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725000163
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