Impact of lipointersil and closaverm A on the antioxidant status of cows with fasciolosis
One of the most prevalent and dangerous helminth infections in large and small ruminants is fasciolosis, which causes significant economic losses in animal husbandry, including reduced milk and meat productivity, deterioration in product quality, and costs associated with treatment and prevention me...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv
2024-05-01
|
| Series: | Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки |
| Subjects: | |
| Online Access: | https://nvlvet.com.ua/index.php/journal/article/view/5176 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | One of the most prevalent and dangerous helminth infections in large and small ruminants is fasciolosis, which causes significant economic losses in animal husbandry, including reduced milk and meat productivity, deterioration in product quality, and costs associated with treatment and prevention measures. According to the literature, various adverse factors, including fasciolosis, significantly enhance cell reactive oxygen species (ROS) reactions through oxidative stress mechanisms. The study aimed to investigate the impact of the liposomal antioxidants Lipointersil and Clozaverm A on the antioxidant status of cows with experimental fasciolosis. Fifteen 4–5-year-old Black-and-White dairy cows were selected and divided into three groups of five animals each. The cows in the control and experimental groups were experimentally infected with adolescariae. In the first experimental group, cows received intra-muscular injections of Clozaverm A at 0.5 ml per 10 kg of body weight after experimental fasciolosis induction. The second experimental group received the same dose of Clozaverm A along with Lipointersil at a dose of 6 ml per animal. Based on the research conducted, it was found that fasciolosis suppresses the activity of antioxidant defense enzymes in the host liver, evidenced by decreased catalase and superoxide dismutase activity and increased levels of lipid hydroperoxides and TBK-active products in their blood. The administration of Lipointersil and Clozaverm A to cows with experimental fasciolosis improved their antioxidant status. This was accompanied by a 46.7 % increase in superoxide dismutase activity (P < 0.001) and a 30.2% increase in catalase activity (P < 0.001) in their blood. Furthermore, there was a suppression of lipid peroxidation processes indicated by a 31.3 % decrease in lipid hydroperoxide levels (P < 0.001) and an 18.8 % decrease in TBC-active products (P < 0.001). |
|---|---|
| ISSN: | 2518-7554 2518-1327 |