Pyruvate decarboxylase and its lysine succinylation contribute to the development and metabolite biosynthesis in pathogenic fungus Aspergillus flavus

Pyruvate decarboxylase and its lysine succinylation contribute to the development and metabolite biosynthesis in pathogenic fungus Aspergillus flavus

This study evaluates the effects of pyruvate decarboxylase and its lysine succinylation (Ksucc) on the development of Aspergillus flavus and the production of secondary metabolites. Mutant strains, including the knockout (∆pdc1), pdc1 point mutants (K258R and K258E) and complementary (∆pdc1.com) wer...

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Bibliographic Details
Main Authors: Guoqi Li, Elisabeth Tumukunde, Yuanyuan Chen, Yao Zhang, Yunlu Kuang, John Adejor, Meifang Wen, Shihua Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-07-01
Series:Mycology
Subjects:
Pyruvate decarboxylase
Aspergillus flavus
aflatoxin
pathogenicity
secondary metabolites
Online Access:https://www.tandfonline.com/doi/10.1080/21501203.2025.2522081
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