Myeloid gasdermin D drives early-stage T cell immunity and peripheral inflammation in a mouse model of Alzheimer’s disease

Myeloid gasdermin D drives early-stage T cell immunity and peripheral inflammation in a mouse model of Alzheimer’s disease

Abstract Background It is now realized that peripheral inflammation and abnormal immune responses, especially T cells, contribute to the development of Alzheimer’s disease (AD). Gasdermin D (GSDMD) -mediated pyroptosis has been associated with several neuroinflammatory diseases, but whether GSDMD is...

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Bibliographic Details
Main Authors: Wenjuan Rui, Yuqing Wu, Yongbing Yang, Wenting Xie, Dengli Qin, Jie Ming, Zhihan Ye, Liu Lu, Ming Zong, Xianglong Tang, Lieying Fan, Sheng Li
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
GSDMD
Peripheral inflammation
T cell
Online Access:https://doi.org/10.1186/s12974-024-03255-9
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