Exploring molecular determinants and pharmacokinetic properties of IgG1-scFv bispecific antibodies

Exploring molecular determinants and pharmacokinetic properties of IgG1-scFv bispecific antibodies

Bispecific antibodies (BsAbs) capable of recognizing two distinct epitopes or antigens offer promising therapeutic options for various diseases by targeting multiple pathways. The favorable pharmacokinetic (PK) properties of monoclonal antibodies (mAbs) are crucial, as they directly influence patien...

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Bibliographic Details
Main Authors: Kristina M.J. Aertker, Minu Ravindra Pilvankar, Tobias M. Prass, Michaela Blech, Fabian Higel, Srinath Kasturirangan
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Biophysical assessment
bispecific antibody
FcRn
in silico developability
pharmacokinetics (PK)
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2318817
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