Piezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-κB/p65 axis
Abstract Vibration induced damage to the peripheral circulatory system is thought to be an early stage of hand-arm vibration syndrome (HAVS) caused by occupational exposure to hand-transmitted vibration (HTV). This study investigated the mechanisms underlying vibration-induced vascular injury, focus...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07524-y |
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| author | Yingshan Zeng Zhiquan Wu Mengtian Xiong Zhishan Liang Ziyu Chen Huimin Huang Hongyu Yang Qingsong Chen |
| author_facet | Yingshan Zeng Zhiquan Wu Mengtian Xiong Zhishan Liang Ziyu Chen Huimin Huang Hongyu Yang Qingsong Chen |
| author_sort | Yingshan Zeng |
| collection | DOAJ |
| description | Abstract Vibration induced damage to the peripheral circulatory system is thought to be an early stage of hand-arm vibration syndrome (HAVS) caused by occupational exposure to hand-transmitted vibration (HTV). This study investigated the mechanisms underlying vibration-induced vascular injury, focusing on the role of Piezo1, a mechanosensitive channel, and its association with the NF-κB/p65 signaling pathway. We demonstrated that vibration exposure leads to Piezo1-mediated upregulation of angiogenic chemokines, including CCL2, CCL5, CXCL1, CXCL2, and CXCL10, through the NF-κB/p65 pathway. To mimic the effects of vibration, a rat vibration model and a cellular vibration model were used. Animal and cellular models showed that vibration-induced vascular dysfunction while increasing Piezo1 expression. Piezo1 knockdown or p65 inhibition attenuated these effects, suggesting a crucial role for the Piezo1-NF-κB/p65 axis in vascular dysfunction. Furthermore, chemokines were identified as potential biomarkers for early diagnosis of HAVS in occupationally exposed individuals. These results highlight Piezo1 and the NF-κB/p65 pathway as potential therapeutic targets for HAVS and underscore the need for further validation in human samples and exploration of additional signaling mechanisms involved in vibration-induced vascular injury. |
| format | Article |
| id | doaj-art-1c5eb314444c4ed9b3d426dc22e433b0 |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-1c5eb314444c4ed9b3d426dc22e433b02025-01-26T12:48:15ZengNature PortfolioCommunications Biology2399-36422025-01-018111210.1038/s42003-025-07524-yPiezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-κB/p65 axisYingshan Zeng0Zhiquan Wu1Mengtian Xiong2Zhishan Liang3Ziyu Chen4Huimin Huang5Hongyu Yang6Qingsong Chen7Department of Occupational and Environmental Health, School of Public Health, Guangdong Pharmaceutical UniversityDepartment of Occupational and Environmental Health, School of Public Health, Guangdong Pharmaceutical UniversityDepartment of Occupational and Environmental Health, School of Public Health, Guangdong Pharmaceutical UniversityDepartment of Occupational and Environmental Health, School of Public Health, Guangdong Pharmaceutical UniversityDepartment of Occupational and Environmental Health, School of Public Health, Guangdong Pharmaceutical UniversityDepartment of Occupational and Environmental Health, School of Public Health, Guangdong Pharmaceutical UniversityDepartment of Occupational and Environmental Health, School of Public Health, Guangdong Pharmaceutical UniversityDepartment of Occupational and Environmental Health, School of Public Health, Guangdong Pharmaceutical UniversityAbstract Vibration induced damage to the peripheral circulatory system is thought to be an early stage of hand-arm vibration syndrome (HAVS) caused by occupational exposure to hand-transmitted vibration (HTV). This study investigated the mechanisms underlying vibration-induced vascular injury, focusing on the role of Piezo1, a mechanosensitive channel, and its association with the NF-κB/p65 signaling pathway. We demonstrated that vibration exposure leads to Piezo1-mediated upregulation of angiogenic chemokines, including CCL2, CCL5, CXCL1, CXCL2, and CXCL10, through the NF-κB/p65 pathway. To mimic the effects of vibration, a rat vibration model and a cellular vibration model were used. Animal and cellular models showed that vibration-induced vascular dysfunction while increasing Piezo1 expression. Piezo1 knockdown or p65 inhibition attenuated these effects, suggesting a crucial role for the Piezo1-NF-κB/p65 axis in vascular dysfunction. Furthermore, chemokines were identified as potential biomarkers for early diagnosis of HAVS in occupationally exposed individuals. These results highlight Piezo1 and the NF-κB/p65 pathway as potential therapeutic targets for HAVS and underscore the need for further validation in human samples and exploration of additional signaling mechanisms involved in vibration-induced vascular injury.https://doi.org/10.1038/s42003-025-07524-y |
| spellingShingle | Yingshan Zeng Zhiquan Wu Mengtian Xiong Zhishan Liang Ziyu Chen Huimin Huang Hongyu Yang Qingsong Chen Piezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-κB/p65 axis Communications Biology |
| title | Piezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-κB/p65 axis |
| title_full | Piezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-κB/p65 axis |
| title_fullStr | Piezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-κB/p65 axis |
| title_full_unstemmed | Piezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-κB/p65 axis |
| title_short | Piezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-κB/p65 axis |
| title_sort | piezo1 promotes vibration induced vascular smooth muscle injury by regulating the nf κb p65 axis |
| url | https://doi.org/10.1038/s42003-025-07524-y |
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