An overview of the role of MMP-8 and ADAM-33 in bronchial asthma
Matrix metalloproteinases (MMPs) and A disintegrin and metalloproteinases (ADAMs) are enzymes able to degrade a variety of protein components of the extracellular matrix. Due to the diverse role of MMPs and ADAMs, they are involved in the pathogenesis of many diseases, including chronic inflammatory...
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Taylor & Francis Group
2024-12-01
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| Series: | Biotechnology & Biotechnological Equipment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13102818.2024.2373855 |
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| author | Kahan Celik Tanya Tacheva Dimo Dimov Tatyana Vlaykova |
| author_facet | Kahan Celik Tanya Tacheva Dimo Dimov Tatyana Vlaykova |
| author_sort | Kahan Celik |
| collection | DOAJ |
| description | Matrix metalloproteinases (MMPs) and A disintegrin and metalloproteinases (ADAMs) are enzymes able to degrade a variety of protein components of the extracellular matrix. Due to the diverse role of MMPs and ADAMs, they are involved in the pathogenesis of many diseases, including chronic inflammatory lung diseases. In this review, the objective is to summarize the current knowledge about the role of the two enzymes from the respective families, namely MMP-8 and ADAM-33, in Bronchial asthma in order to explore the possibility for their expression, polymorphisms or serum/BAL (Bronchoalveolar Lavage) concentration to be used as biomarkers or targets for future target therapy. Considering the key functions of MMP-8 and ADAM-33 in many pathologic conditions, development of proper inhibitors of their action might be useful tools in the treatment approaches. However, a lot of knowledge has yet to be gained about these enzymes and their role in bronchial asthma, since some of the mechanisms are unknown or not discovered yet. |
| format | Article |
| id | doaj-art-1c5cbef95eca47b7af08b826b1f84a82 |
| institution | OA Journals |
| issn | 1310-2818 1314-3530 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Biotechnology & Biotechnological Equipment |
| spelling | doaj-art-1c5cbef95eca47b7af08b826b1f84a822025-08-20T02:38:55ZengTaylor & Francis GroupBiotechnology & Biotechnological Equipment1310-28181314-35302024-12-0138110.1080/13102818.2024.2373855An overview of the role of MMP-8 and ADAM-33 in bronchial asthmaKahan Celik0Tanya Tacheva1Dimo Dimov2Tatyana Vlaykova3Medical Faculty, Trakia University, Stara Zagora, BulgariaDepartment of Medical Chemistry and Biochemistry, Medical Faculty, Trakia University, Stara Zagora, BulgariaDepartment of Medical Chemistry and Biochemistry, Medical Faculty, Trakia University, Stara Zagora, BulgariaDepartment of Medical Chemistry and Biochemistry, Medical Faculty, Trakia University, Stara Zagora, BulgariaMatrix metalloproteinases (MMPs) and A disintegrin and metalloproteinases (ADAMs) are enzymes able to degrade a variety of protein components of the extracellular matrix. Due to the diverse role of MMPs and ADAMs, they are involved in the pathogenesis of many diseases, including chronic inflammatory lung diseases. In this review, the objective is to summarize the current knowledge about the role of the two enzymes from the respective families, namely MMP-8 and ADAM-33, in Bronchial asthma in order to explore the possibility for their expression, polymorphisms or serum/BAL (Bronchoalveolar Lavage) concentration to be used as biomarkers or targets for future target therapy. Considering the key functions of MMP-8 and ADAM-33 in many pathologic conditions, development of proper inhibitors of their action might be useful tools in the treatment approaches. However, a lot of knowledge has yet to be gained about these enzymes and their role in bronchial asthma, since some of the mechanisms are unknown or not discovered yet.https://www.tandfonline.com/doi/10.1080/13102818.2024.2373855MMP-8ADAM-33lunginflammationbronchial asthma |
| spellingShingle | Kahan Celik Tanya Tacheva Dimo Dimov Tatyana Vlaykova An overview of the role of MMP-8 and ADAM-33 in bronchial asthma Biotechnology & Biotechnological Equipment MMP-8 ADAM-33 lung inflammation bronchial asthma |
| title | An overview of the role of MMP-8 and ADAM-33 in bronchial asthma |
| title_full | An overview of the role of MMP-8 and ADAM-33 in bronchial asthma |
| title_fullStr | An overview of the role of MMP-8 and ADAM-33 in bronchial asthma |
| title_full_unstemmed | An overview of the role of MMP-8 and ADAM-33 in bronchial asthma |
| title_short | An overview of the role of MMP-8 and ADAM-33 in bronchial asthma |
| title_sort | overview of the role of mmp 8 and adam 33 in bronchial asthma |
| topic | MMP-8 ADAM-33 lung inflammation bronchial asthma |
| url | https://www.tandfonline.com/doi/10.1080/13102818.2024.2373855 |
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