Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021
Abstract Background Gallbladder and biliary tract cancer (GBTC) denotes a range of invasive tumors. Emerging evidence has revealed a rising trend in the incidence of early-onset GBTC (EOGBTC) patients, referring to individuals under the age of 50 years old. We conducted an epidemiological study to a...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-025-04080-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849238280456896512 |
|---|---|
| author | Jin Liu Wei Fang XiangYi He XianTu Zhang Hong Liu |
| author_facet | Jin Liu Wei Fang XiangYi He XianTu Zhang Hong Liu |
| author_sort | Jin Liu |
| collection | DOAJ |
| description | Abstract Background Gallbladder and biliary tract cancer (GBTC) denotes a range of invasive tumors. Emerging evidence has revealed a rising trend in the incidence of early-onset GBTC (EOGBTC) patients, referring to individuals under the age of 50 years old. We conducted an epidemiological study to assess the disease burden of EOGBTC. Methods Data on EOGBTC from 1990 to 2021 were sourced from the Global Burden of Disease Study 2021. Average annual percentage changes (AAPCs) and age-standardized rates (ASRs) were calculated to assess overall trends in the burden of EOGBTC. Statistical models including decomposition analysis, health inequality analysis, and Nordpred were utilized in the research. Results The study indicated over 24,555 prevalent cases, 13,611 new cases, and roughly 8777 deaths of EOGBTC in 2021. The global ASR of incidence and prevalence displayed increased trends, while the ASR of mortality and disability-adjusted life years (DALYs) were downward trends. East Asia and South Asia represented the heaviest disease burdens. The disease burden is mainly concentrated in the middle, low-middle, and low SDI regions. Decomposition analysis revealed that the primary influence of disease burden was population growth. Health inequalities showed improvement. Nordpred model forecasted that by 2040, global EOGBTC incidence and prevalence may steadily increase, while the deaths and DALYs display a general downward trend. Conclusions The overall burden of EOGBTC continues to be considerable, especially in regions with middle, low-middle, and low SDI levels. These findings underscore the necessity for innovative healthcare strategies to alleviate the burden faced by EOGBTC globally. |
| format | Article |
| id | doaj-art-1c5898bee5b74b56886732db73c5ebcc |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-1c5898bee5b74b56886732db73c5ebcc2025-08-20T04:01:41ZengBMCBMC Gastroenterology1471-230X2025-07-0125111310.1186/s12876-025-04080-xGlobal burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021Jin Liu0Wei Fang1XiangYi He2XianTu Zhang3Hong Liu4Department of Pathology, Huzhou Central HospitalDepartment of Pathology, Huzhou Central HospitalDepartment of Pathology, Huzhou Central HospitalDepartment of Pathology, Xixi Hospital of HangzhouDepartment of Pathology, Xixi Hospital of HangzhouAbstract Background Gallbladder and biliary tract cancer (GBTC) denotes a range of invasive tumors. Emerging evidence has revealed a rising trend in the incidence of early-onset GBTC (EOGBTC) patients, referring to individuals under the age of 50 years old. We conducted an epidemiological study to assess the disease burden of EOGBTC. Methods Data on EOGBTC from 1990 to 2021 were sourced from the Global Burden of Disease Study 2021. Average annual percentage changes (AAPCs) and age-standardized rates (ASRs) were calculated to assess overall trends in the burden of EOGBTC. Statistical models including decomposition analysis, health inequality analysis, and Nordpred were utilized in the research. Results The study indicated over 24,555 prevalent cases, 13,611 new cases, and roughly 8777 deaths of EOGBTC in 2021. The global ASR of incidence and prevalence displayed increased trends, while the ASR of mortality and disability-adjusted life years (DALYs) were downward trends. East Asia and South Asia represented the heaviest disease burdens. The disease burden is mainly concentrated in the middle, low-middle, and low SDI regions. Decomposition analysis revealed that the primary influence of disease burden was population growth. Health inequalities showed improvement. Nordpred model forecasted that by 2040, global EOGBTC incidence and prevalence may steadily increase, while the deaths and DALYs display a general downward trend. Conclusions The overall burden of EOGBTC continues to be considerable, especially in regions with middle, low-middle, and low SDI levels. These findings underscore the necessity for innovative healthcare strategies to alleviate the burden faced by EOGBTC globally.https://doi.org/10.1186/s12876-025-04080-xGallbladder and biliary tract cancerEarly-onsetEpidemiologyGlobal burden of diseaseDisability-adjusted life-years |
| spellingShingle | Jin Liu Wei Fang XiangYi He XianTu Zhang Hong Liu Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021 BMC Gastroenterology Gallbladder and biliary tract cancer Early-onset Epidemiology Global burden of disease Disability-adjusted life-years |
| title | Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021 |
| title_full | Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021 |
| title_fullStr | Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021 |
| title_full_unstemmed | Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021 |
| title_short | Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021 |
| title_sort | global burden of early onset gallbladder and biliary tract cancer from 1990 to 2021 |
| topic | Gallbladder and biliary tract cancer Early-onset Epidemiology Global burden of disease Disability-adjusted life-years |
| url | https://doi.org/10.1186/s12876-025-04080-x |
| work_keys_str_mv | AT jinliu globalburdenofearlyonsetgallbladderandbiliarytractcancerfrom1990to2021 AT weifang globalburdenofearlyonsetgallbladderandbiliarytractcancerfrom1990to2021 AT xiangyihe globalburdenofearlyonsetgallbladderandbiliarytractcancerfrom1990to2021 AT xiantuzhang globalburdenofearlyonsetgallbladderandbiliarytractcancerfrom1990to2021 AT hongliu globalburdenofearlyonsetgallbladderandbiliarytractcancerfrom1990to2021 |