LONG-TERM ADMINISTRATION OF TAMSULOSIN INCREASE APOPTOSIS ON PROSTATE CELL OF BPH PATIENT: STUDY ON TGF-ß1, SMAD-4, AND NF- KB
Objective: In this study we aimed to know further mechanism and relation between the long-term usage of tamsulosin with the apoptotic mechanism on prostatic cells of BPH patients qualitatively. Material & Methods: A Case-control study from prostate resection specimens. Subjects were 20 male who...
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IKATAN AHLI UROLOGI INDONESIA
2025-05-01
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| Series: | Jurnal Urologi Indonesia |
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| Online Access: | http://www.juri.urologi.or.id/juri/article/view/1028 |
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| author | Faathir Baihaqi Ghifary Besut Daryanto Karyono Mintaroem |
| author_facet | Faathir Baihaqi Ghifary Besut Daryanto Karyono Mintaroem |
| author_sort | Faathir Baihaqi Ghifary |
| collection | DOAJ |
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Objective: In this study we aimed to know further mechanism and relation between the long-term usage of tamsulosin with the apoptotic mechanism on prostatic cells of BPH patients qualitatively. Material & Methods: A Case-control study from prostate resection specimens. Subjects were 20 male who underwent the TUR-P procedure, were divided into two groups equally, a group who got long-term administration of tamsulosin 0.4 mg, and one without tamsulosin. TGF-β1 and Smad-4 expression was measured by Enzyme-Linked Immunosorbent Assay (ELISA), meanwhile expression of NF- kB measured by immunohistochemistry assay. Results: There was a significant difference on the Independent T-Test that showed an increase in expression of TGF-β1 and Smad-4 expression and a decrease in expression of NF- kB p= 0.003 (p<0,05) from a group of patients who got long-term oral administration of tamsulosin 0.4 mg, compared with a group of patients who didn’t get any treatment. Conclusion: Long-term tamsulosin would induce an apoptotic process in the prostate cells shown by the activity of TGF-β1, Smad-4, and NF- kB.
Keywords: BPH, tamsulosin, TGF-β1, Smad-4, NF- kB, apoptosis
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| format | Article |
| id | doaj-art-1c54069a489644e89abe0f17405c84e2 |
| institution | Kabale University |
| issn | 0853-442X 2355-1402 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | IKATAN AHLI UROLOGI INDONESIA |
| record_format | Article |
| series | Jurnal Urologi Indonesia |
| spelling | doaj-art-1c54069a489644e89abe0f17405c84e22025-08-20T03:47:41ZengIKATAN AHLI UROLOGI INDONESIAJurnal Urologi Indonesia0853-442X2355-14022025-05-0132210.32421/juri.v32i2.1028LONG-TERM ADMINISTRATION OF TAMSULOSIN INCREASE APOPTOSIS ON PROSTATE CELL OF BPH PATIENT: STUDY ON TGF-ß1, SMAD-4, AND NF- KBFaathir Baihaqi Ghifary0Besut Daryanto1Karyono Mintaroem2Master Program of Biomedical Science, Faculty of Medicine/University of Brawijaya, Malang.Department of Urology, Faculty of Medicine/University of Brawijaya, Saiful Anwar General Hospital, Malang.Department of Anatomical Pathology, Faculty of Medicine/University of Brawijaya, Saiful Anwar General Hospital, Malang. Objective: In this study we aimed to know further mechanism and relation between the long-term usage of tamsulosin with the apoptotic mechanism on prostatic cells of BPH patients qualitatively. Material & Methods: A Case-control study from prostate resection specimens. Subjects were 20 male who underwent the TUR-P procedure, were divided into two groups equally, a group who got long-term administration of tamsulosin 0.4 mg, and one without tamsulosin. TGF-β1 and Smad-4 expression was measured by Enzyme-Linked Immunosorbent Assay (ELISA), meanwhile expression of NF- kB measured by immunohistochemistry assay. Results: There was a significant difference on the Independent T-Test that showed an increase in expression of TGF-β1 and Smad-4 expression and a decrease in expression of NF- kB p= 0.003 (p<0,05) from a group of patients who got long-term oral administration of tamsulosin 0.4 mg, compared with a group of patients who didn’t get any treatment. Conclusion: Long-term tamsulosin would induce an apoptotic process in the prostate cells shown by the activity of TGF-β1, Smad-4, and NF- kB. Keywords: BPH, tamsulosin, TGF-β1, Smad-4, NF- kB, apoptosis http://www.juri.urologi.or.id/juri/article/view/1028BPHTamsulosinTGF-β1Smad-4NF- kBApoptosis |
| spellingShingle | Faathir Baihaqi Ghifary Besut Daryanto Karyono Mintaroem LONG-TERM ADMINISTRATION OF TAMSULOSIN INCREASE APOPTOSIS ON PROSTATE CELL OF BPH PATIENT: STUDY ON TGF-ß1, SMAD-4, AND NF- KB Jurnal Urologi Indonesia BPH Tamsulosin TGF-β1 Smad-4 NF- kB Apoptosis |
| title | LONG-TERM ADMINISTRATION OF TAMSULOSIN INCREASE APOPTOSIS ON PROSTATE CELL OF BPH PATIENT: STUDY ON TGF-ß1, SMAD-4, AND NF- KB |
| title_full | LONG-TERM ADMINISTRATION OF TAMSULOSIN INCREASE APOPTOSIS ON PROSTATE CELL OF BPH PATIENT: STUDY ON TGF-ß1, SMAD-4, AND NF- KB |
| title_fullStr | LONG-TERM ADMINISTRATION OF TAMSULOSIN INCREASE APOPTOSIS ON PROSTATE CELL OF BPH PATIENT: STUDY ON TGF-ß1, SMAD-4, AND NF- KB |
| title_full_unstemmed | LONG-TERM ADMINISTRATION OF TAMSULOSIN INCREASE APOPTOSIS ON PROSTATE CELL OF BPH PATIENT: STUDY ON TGF-ß1, SMAD-4, AND NF- KB |
| title_short | LONG-TERM ADMINISTRATION OF TAMSULOSIN INCREASE APOPTOSIS ON PROSTATE CELL OF BPH PATIENT: STUDY ON TGF-ß1, SMAD-4, AND NF- KB |
| title_sort | long term administration of tamsulosin increase apoptosis on prostate cell of bph patient study on tgf ss1 smad 4 and nf kb |
| topic | BPH Tamsulosin TGF-β1 Smad-4 NF- kB Apoptosis |
| url | http://www.juri.urologi.or.id/juri/article/view/1028 |
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