Case report: a rare concurrence of dense deposit disease in an adolescent patient with IgA nephropathy

Abstract Background Dense deposit disease (DDD) is a rare renal disorder major affecting adolescents and children, characterized by an absence of distinctive clinical symptoms. Its coexistence with other renal conditions complicates both diagnosis and treatment in clinical practice. Case presentatio...

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Main Authors: Jian-Hui Zhang, Hong-Ping Yu, Ying Chen, Qian Chen, Xiao-Ling Zheng, Jie-Wei Luo, Li Zhang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Pediatrics
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Online Access:https://doi.org/10.1186/s12887-025-05415-z
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author Jian-Hui Zhang
Hong-Ping Yu
Ying Chen
Qian Chen
Xiao-Ling Zheng
Jie-Wei Luo
Li Zhang
author_facet Jian-Hui Zhang
Hong-Ping Yu
Ying Chen
Qian Chen
Xiao-Ling Zheng
Jie-Wei Luo
Li Zhang
author_sort Jian-Hui Zhang
collection DOAJ
description Abstract Background Dense deposit disease (DDD) is a rare renal disorder major affecting adolescents and children, characterized by an absence of distinctive clinical symptoms. Its coexistence with other renal conditions complicates both diagnosis and treatment in clinical practice. Case presentation We described a 15-year-old male adolescent presenting with nephrotic syndrome as the initial manifestation, with urinalysis indicating significantly elevated protein and erythrocytes. Unexpectedly, the renal pathological biopsy of the patient exhibited strong positivity for both IgA and C3, characterized by petaloid deposition of C3 along glomerular capillary loops and the glomerular mesangial region, as well as linear deposition in Bowman’s capsule and portions of the renal tubular basement membrane. Consequently, the patient was diagnosed with both DDD and IgA nephropathy. The presence of both in a single patient may result in more intricate pathogenic pathways. Conclusions This specific case elucidates the pathological characteristics of both diseases while investigating the intricate connections and lesion correlations that may occur between them, offering novel insights into their pathogenesis.
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institution Kabale University
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publishDate 2025-01-01
publisher BMC
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series BMC Pediatrics
spelling doaj-art-1c539d5a9bc243e59da08dc4cae7d18a2025-01-26T12:52:47ZengBMCBMC Pediatrics1471-24312025-01-012511510.1186/s12887-025-05415-zCase report: a rare concurrence of dense deposit disease in an adolescent patient with IgA nephropathyJian-Hui Zhang0Hong-Ping Yu1Ying Chen2Qian Chen3Xiao-Ling Zheng4Jie-Wei Luo5Li Zhang6Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial HospitalDepartment of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial HospitalDepartment of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial HospitalDepartment of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial HospitalDepartment of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial HospitalDepartment of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial HospitalDepartment of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial HospitalAbstract Background Dense deposit disease (DDD) is a rare renal disorder major affecting adolescents and children, characterized by an absence of distinctive clinical symptoms. Its coexistence with other renal conditions complicates both diagnosis and treatment in clinical practice. Case presentation We described a 15-year-old male adolescent presenting with nephrotic syndrome as the initial manifestation, with urinalysis indicating significantly elevated protein and erythrocytes. Unexpectedly, the renal pathological biopsy of the patient exhibited strong positivity for both IgA and C3, characterized by petaloid deposition of C3 along glomerular capillary loops and the glomerular mesangial region, as well as linear deposition in Bowman’s capsule and portions of the renal tubular basement membrane. Consequently, the patient was diagnosed with both DDD and IgA nephropathy. The presence of both in a single patient may result in more intricate pathogenic pathways. Conclusions This specific case elucidates the pathological characteristics of both diseases while investigating the intricate connections and lesion correlations that may occur between them, offering novel insights into their pathogenesis.https://doi.org/10.1186/s12887-025-05415-zDense deposit diseaseIgA nephropathyPathological complicationsCase report
spellingShingle Jian-Hui Zhang
Hong-Ping Yu
Ying Chen
Qian Chen
Xiao-Ling Zheng
Jie-Wei Luo
Li Zhang
Case report: a rare concurrence of dense deposit disease in an adolescent patient with IgA nephropathy
BMC Pediatrics
Dense deposit disease
IgA nephropathy
Pathological complications
Case report
title Case report: a rare concurrence of dense deposit disease in an adolescent patient with IgA nephropathy
title_full Case report: a rare concurrence of dense deposit disease in an adolescent patient with IgA nephropathy
title_fullStr Case report: a rare concurrence of dense deposit disease in an adolescent patient with IgA nephropathy
title_full_unstemmed Case report: a rare concurrence of dense deposit disease in an adolescent patient with IgA nephropathy
title_short Case report: a rare concurrence of dense deposit disease in an adolescent patient with IgA nephropathy
title_sort case report a rare concurrence of dense deposit disease in an adolescent patient with iga nephropathy
topic Dense deposit disease
IgA nephropathy
Pathological complications
Case report
url https://doi.org/10.1186/s12887-025-05415-z
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