PREDICTION ENDOMETRIAL CANCER IN WOMEN WITH ENDOMETRIAL HYPERPLASTIC PROCESSES IN PREMENOPAUSAL
We have identified risk factors and determined their significance and relative risk in endometrial oncotransformation based on mathematical analysis of clinical and anamnestic data and molecular-biological indicators. The structural, functional and molecular mechanisms of hyperplastic processes of e...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2016-09-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/316 |
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| author | A. L. Unanyan I. S. Sidorova E. A. Kogan D. V. Baburin |
| author_facet | A. L. Unanyan I. S. Sidorova E. A. Kogan D. V. Baburin |
| author_sort | A. L. Unanyan |
| collection | DOAJ |
| description | We have identified risk factors and determined their significance and relative risk in endometrial oncotransformation based on mathematical analysis of clinical and anamnestic data and molecular-biological indicators. The structural, functional and molecular mechanisms of hyperplastic processes of endometrium in premenopausal women were investigated based on a complex immunohistochemical studies. Our study revealed the features of the expression of tumor suppressor gene PTEN and the marker of tight junctions Claudin 3 and the proliferation marker Ki-67 in epithelial and stromal components based on morphological variant of the pathological process of the endometrium.We have performed a comparative analysis of clinical, morphological and molecular biological studies and as a result suggested a new approach to the study of endometrial hyperplastic processes in premenopausal women, that helps to detect women with increased risk of endometrial oncopathology and gives opportunity to perform pathogenetically based approach to therapy. |
| format | Article |
| id | doaj-art-1c4feff02391471aa53550ebfa51cda3 |
| institution | DOAJ |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2016-09-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-1c4feff02391471aa53550ebfa51cda32025-08-20T02:53:57ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942016-09-01611824314PREDICTION ENDOMETRIAL CANCER IN WOMEN WITH ENDOMETRIAL HYPERPLASTIC PROCESSES IN PREMENOPAUSALA. L. Unanyan0I. S. Sidorova1E. A. Kogan2D. V. Baburin3GOU VPO First MSMU named after I.M. SechenovGOU VPO First MSMU named after I.M. SechenovScientific Center of Obstetrics, Gynecology and Perinatology named after academician V.I. KulakovGOU VPO First MSMU named after I.M. SechenovWe have identified risk factors and determined their significance and relative risk in endometrial oncotransformation based on mathematical analysis of clinical and anamnestic data and molecular-biological indicators. The structural, functional and molecular mechanisms of hyperplastic processes of endometrium in premenopausal women were investigated based on a complex immunohistochemical studies. Our study revealed the features of the expression of tumor suppressor gene PTEN and the marker of tight junctions Claudin 3 and the proliferation marker Ki-67 in epithelial and stromal components based on morphological variant of the pathological process of the endometrium.We have performed a comparative analysis of clinical, morphological and molecular biological studies and as a result suggested a new approach to the study of endometrial hyperplastic processes in premenopausal women, that helps to detect women with increased risk of endometrial oncopathology and gives opportunity to perform pathogenetically based approach to therapy.https://www.gynecology.su/jour/article/view/316endometrial hyperplasiapremenopausaloncotransformation of endometriumcancer of the endometriumptenclaudin 3ki-67binary logistic regressionthe risk of developing endometrial cancertarget therapy |
| spellingShingle | A. L. Unanyan I. S. Sidorova E. A. Kogan D. V. Baburin PREDICTION ENDOMETRIAL CANCER IN WOMEN WITH ENDOMETRIAL HYPERPLASTIC PROCESSES IN PREMENOPAUSAL Акушерство, гинекология и репродукция endometrial hyperplasia premenopausal oncotransformation of endometrium cancer of the endometrium pten claudin 3 ki-67 binary logistic regression the risk of developing endometrial cancer target therapy |
| title | PREDICTION ENDOMETRIAL CANCER IN WOMEN WITH ENDOMETRIAL HYPERPLASTIC PROCESSES IN PREMENOPAUSAL |
| title_full | PREDICTION ENDOMETRIAL CANCER IN WOMEN WITH ENDOMETRIAL HYPERPLASTIC PROCESSES IN PREMENOPAUSAL |
| title_fullStr | PREDICTION ENDOMETRIAL CANCER IN WOMEN WITH ENDOMETRIAL HYPERPLASTIC PROCESSES IN PREMENOPAUSAL |
| title_full_unstemmed | PREDICTION ENDOMETRIAL CANCER IN WOMEN WITH ENDOMETRIAL HYPERPLASTIC PROCESSES IN PREMENOPAUSAL |
| title_short | PREDICTION ENDOMETRIAL CANCER IN WOMEN WITH ENDOMETRIAL HYPERPLASTIC PROCESSES IN PREMENOPAUSAL |
| title_sort | prediction endometrial cancer in women with endometrial hyperplastic processes in premenopausal |
| topic | endometrial hyperplasia premenopausal oncotransformation of endometrium cancer of the endometrium pten claudin 3 ki-67 binary logistic regression the risk of developing endometrial cancer target therapy |
| url | https://www.gynecology.su/jour/article/view/316 |
| work_keys_str_mv | AT alunanyan predictionendometrialcancerinwomenwithendometrialhyperplasticprocessesinpremenopausal AT issidorova predictionendometrialcancerinwomenwithendometrialhyperplasticprocessesinpremenopausal AT eakogan predictionendometrialcancerinwomenwithendometrialhyperplasticprocessesinpremenopausal AT dvbaburin predictionendometrialcancerinwomenwithendometrialhyperplasticprocessesinpremenopausal |