Cell identity and 5-hydroxymethylcytosine
Abstract Epigenetic factors underlie cellular identity through the regulation of transcriptional networks that establish a cell’s phenotype and function. Cell conversions are directed by transcription factor binding at target DNA which induce changes to identity-specific gene regulatory programs. Th...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | Epigenetics & Chromatin |
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| Online Access: | https://doi.org/10.1186/s13072-025-00601-w |
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| _version_ | 1850111587401072640 |
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| author | Floris Honig Adele Murrell |
| author_facet | Floris Honig Adele Murrell |
| author_sort | Floris Honig |
| collection | DOAJ |
| description | Abstract Epigenetic factors underlie cellular identity through the regulation of transcriptional networks that establish a cell’s phenotype and function. Cell conversions are directed by transcription factor binding at target DNA which induce changes to identity-specific gene regulatory programs. The degree of cell plasticity is determined by the interplay of epigenetic mechanisms to create a landscape susceptible to such binding events. 5-hydroxymethylcytosine, a key intermediate during the process of DNA demethylation, is an epigenetic modification involved in controlling these epigenetic dynamics related to cell identity. Here, the role of 5-hydroxcymethylcytosine during cell identity conversions, including its relationship with other main epigenetic mechanisms, is reviewed. |
| format | Article |
| id | doaj-art-1c4daf4df3ca40308e669d8ac2ac4e1e |
| institution | OA Journals |
| issn | 1756-8935 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Epigenetics & Chromatin |
| spelling | doaj-art-1c4daf4df3ca40308e669d8ac2ac4e1e2025-08-20T02:37:36ZengBMCEpigenetics & Chromatin1756-89352025-06-0118111310.1186/s13072-025-00601-wCell identity and 5-hydroxymethylcytosineFloris Honig0Adele Murrell1Department of Life Sciences, University of BathDepartment of Life Sciences, University of BathAbstract Epigenetic factors underlie cellular identity through the regulation of transcriptional networks that establish a cell’s phenotype and function. Cell conversions are directed by transcription factor binding at target DNA which induce changes to identity-specific gene regulatory programs. The degree of cell plasticity is determined by the interplay of epigenetic mechanisms to create a landscape susceptible to such binding events. 5-hydroxymethylcytosine, a key intermediate during the process of DNA demethylation, is an epigenetic modification involved in controlling these epigenetic dynamics related to cell identity. Here, the role of 5-hydroxcymethylcytosine during cell identity conversions, including its relationship with other main epigenetic mechanisms, is reviewed.https://doi.org/10.1186/s13072-025-00601-w5-hydroxymethylcytosineCell identityCell conversionsEpigenetic mechanismsEpigenetic barriers |
| spellingShingle | Floris Honig Adele Murrell Cell identity and 5-hydroxymethylcytosine Epigenetics & Chromatin 5-hydroxymethylcytosine Cell identity Cell conversions Epigenetic mechanisms Epigenetic barriers |
| title | Cell identity and 5-hydroxymethylcytosine |
| title_full | Cell identity and 5-hydroxymethylcytosine |
| title_fullStr | Cell identity and 5-hydroxymethylcytosine |
| title_full_unstemmed | Cell identity and 5-hydroxymethylcytosine |
| title_short | Cell identity and 5-hydroxymethylcytosine |
| title_sort | cell identity and 5 hydroxymethylcytosine |
| topic | 5-hydroxymethylcytosine Cell identity Cell conversions Epigenetic mechanisms Epigenetic barriers |
| url | https://doi.org/10.1186/s13072-025-00601-w |
| work_keys_str_mv | AT florishonig cellidentityand5hydroxymethylcytosine AT adelemurrell cellidentityand5hydroxymethylcytosine |