Effect of photodynamic therapy on vaginal intraepithelial neoplasia grade one: A retrospective cohort study
Objective: To evaluate the efficacy of photodynamic therapy (PDT) for vaginal intraepithelial neoplasia grade 1 (VaIN1) related to high-risk (Hr)-human papillomavirus (HPV). Methods: Participants aged 25–65 years treated for VaIN1 between March 2022 and September 2022 were retrospectively analyzed i...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S157210002500016X |
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| author | Yao Yang Dan Cao Yi Chen Ying Xu Zhenhong Xiong Zhengrong Zhang Dan Wu |
| author_facet | Yao Yang Dan Cao Yi Chen Ying Xu Zhenhong Xiong Zhengrong Zhang Dan Wu |
| author_sort | Yao Yang |
| collection | DOAJ |
| description | Objective: To evaluate the efficacy of photodynamic therapy (PDT) for vaginal intraepithelial neoplasia grade 1 (VaIN1) related to high-risk (Hr)-human papillomavirus (HPV). Methods: Participants aged 25–65 years treated for VaIN1 between March 2022 and September 2022 were retrospectively analyzed into three groups. The PDT and follow-up groups were matched 1:1 for gravidity, HPV type, and quadrants involved. The PDT and CO2 laser groups were compared without matching. Patients were followed up at 6, 12, and 24 months. Results: After matched, the lesion and Hr-HPV clearance rates of the PDT group (89.5%, 89.5%, 92.1%, and 81.6%, 84.2%, 89.5%) were significantly higher than those of the follow-up group (31.6%, 50.0%, 63.2%, and 21.1%, 26.3%, 31.6%, P < 0.05) at 6, 12, and 24 months. But the lesion clearance rates did not differ significantly between the PDT (68.9%, 82.2%, and 91.1%) and CO2 laser groups (68.7%, 78.3%, and 85.5%, P > 0.05) at 6, 12, and 24 months, and so did Hr-HPV clearance rates (PDT as 62.2% and 77.8%, and CO2 laser 54.2% and 61.4%, respectively, P > 0.05) at 6 and 12 months. However, at 24 months, the Hr-HPV clearance rate was higher in the PDT group than in the CO2 laser group (86.7% vs 71.1%, P = 0.047). In the PDT group, none of the lesions progressed. Conclusions: Compared with CO2 laser, PDT resulted in a higher Hr-HPV clearance, as well as a low risk of complications and disease progression. PDT is an effective and noninvasive treatment for VaIN1. |
| format | Article |
| id | doaj-art-1c49bddcfa4e45948497df51d2394fe1 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-1c49bddcfa4e45948497df51d2394fe12025-02-01T04:11:51ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104486Effect of photodynamic therapy on vaginal intraepithelial neoplasia grade one: A retrospective cohort studyYao Yang0Dan Cao1Yi Chen2Ying Xu3Zhenhong Xiong4Zhengrong Zhang5Dan Wu6Cervical Center of The International Peace Maternity & Child Health Hospital of China Welfare Institute, No. 910 Hengshan Road, Xuhui District, Shanghai 200030, ChinaCervical Center of The International Peace Maternity & Child Health Hospital of China Welfare Institute, No. 910 Hengshan Road, Xuhui District, Shanghai 200030, ChinaCervical Center of The International Peace Maternity & Child Health Hospital of China Welfare Institute, No. 910 Hengshan Road, Xuhui District, Shanghai 200030, ChinaCervical Center of The International Peace Maternity & Child Health Hospital of China Welfare Institute, No. 910 Hengshan Road, Xuhui District, Shanghai 200030, ChinaCervical Center of The International Peace Maternity & Child Health Hospital of China Welfare Institute, No. 910 Hengshan Road, Xuhui District, Shanghai 200030, ChinaCorresponding authors.; Cervical Center of The International Peace Maternity & Child Health Hospital of China Welfare Institute, No. 910 Hengshan Road, Xuhui District, Shanghai 200030, ChinaCorresponding authors.; Cervical Center of The International Peace Maternity & Child Health Hospital of China Welfare Institute, No. 910 Hengshan Road, Xuhui District, Shanghai 200030, ChinaObjective: To evaluate the efficacy of photodynamic therapy (PDT) for vaginal intraepithelial neoplasia grade 1 (VaIN1) related to high-risk (Hr)-human papillomavirus (HPV). Methods: Participants aged 25–65 years treated for VaIN1 between March 2022 and September 2022 were retrospectively analyzed into three groups. The PDT and follow-up groups were matched 1:1 for gravidity, HPV type, and quadrants involved. The PDT and CO2 laser groups were compared without matching. Patients were followed up at 6, 12, and 24 months. Results: After matched, the lesion and Hr-HPV clearance rates of the PDT group (89.5%, 89.5%, 92.1%, and 81.6%, 84.2%, 89.5%) were significantly higher than those of the follow-up group (31.6%, 50.0%, 63.2%, and 21.1%, 26.3%, 31.6%, P < 0.05) at 6, 12, and 24 months. But the lesion clearance rates did not differ significantly between the PDT (68.9%, 82.2%, and 91.1%) and CO2 laser groups (68.7%, 78.3%, and 85.5%, P > 0.05) at 6, 12, and 24 months, and so did Hr-HPV clearance rates (PDT as 62.2% and 77.8%, and CO2 laser 54.2% and 61.4%, respectively, P > 0.05) at 6 and 12 months. However, at 24 months, the Hr-HPV clearance rate was higher in the PDT group than in the CO2 laser group (86.7% vs 71.1%, P = 0.047). In the PDT group, none of the lesions progressed. Conclusions: Compared with CO2 laser, PDT resulted in a higher Hr-HPV clearance, as well as a low risk of complications and disease progression. PDT is an effective and noninvasive treatment for VaIN1.http://www.sciencedirect.com/science/article/pii/S157210002500016XHuman papillomavirusPhotodynamic therapyVaginal intraepithelial neoplasiaCO2 laser |
| spellingShingle | Yao Yang Dan Cao Yi Chen Ying Xu Zhenhong Xiong Zhengrong Zhang Dan Wu Effect of photodynamic therapy on vaginal intraepithelial neoplasia grade one: A retrospective cohort study Photodiagnosis and Photodynamic Therapy Human papillomavirus Photodynamic therapy Vaginal intraepithelial neoplasia CO2 laser |
| title | Effect of photodynamic therapy on vaginal intraepithelial neoplasia grade one: A retrospective cohort study |
| title_full | Effect of photodynamic therapy on vaginal intraepithelial neoplasia grade one: A retrospective cohort study |
| title_fullStr | Effect of photodynamic therapy on vaginal intraepithelial neoplasia grade one: A retrospective cohort study |
| title_full_unstemmed | Effect of photodynamic therapy on vaginal intraepithelial neoplasia grade one: A retrospective cohort study |
| title_short | Effect of photodynamic therapy on vaginal intraepithelial neoplasia grade one: A retrospective cohort study |
| title_sort | effect of photodynamic therapy on vaginal intraepithelial neoplasia grade one a retrospective cohort study |
| topic | Human papillomavirus Photodynamic therapy Vaginal intraepithelial neoplasia CO2 laser |
| url | http://www.sciencedirect.com/science/article/pii/S157210002500016X |
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