Serum liquid biopsy for brain tumours: a scoping analysis of practicable approaches in low- and middle-income countries
Approaches to brain tumour diagnosis and detecting recurrence after treatment are costly and significantly invasive. Developing peripheral-sample liquid biopsy tools is the key to enhancing our ability to prognosticate brain tumour subtypes and molecular heterogeneity. The present scoping review wa...
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| Format: | Article |
| Language: | English |
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Pakistan Medical Association
2024-06-01
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| Series: | Journal of the Pakistan Medical Association |
| Online Access: | https://jpma.org.pk/index.php/public_html/article/view/21165 |
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| _version_ | 1849394599254032384 |
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| author | Mohammad Hamza Bajwa Muhammad Awais Khan Faiza Urooj Muhammad Usman Khalid Syed Ather Enam Hafiza Fatima Aziz Kaynat Siddiqui Muhammad Ehsan Bari Nouman Mughal |
| author_facet | Mohammad Hamza Bajwa Muhammad Awais Khan Faiza Urooj Muhammad Usman Khalid Syed Ather Enam Hafiza Fatima Aziz Kaynat Siddiqui Muhammad Ehsan Bari Nouman Mughal |
| author_sort | Mohammad Hamza Bajwa |
| collection | DOAJ |
| description |
Approaches to brain tumour diagnosis and detecting
recurrence after treatment are costly and significantly
invasive. Developing peripheral-sample liquid biopsy
tools is the key to enhancing our ability to prognosticate
brain tumour subtypes and molecular heterogeneity. The
present scoping review was designed to discuss current
updates in liquid biopsy tools for diagnosis and guiding
clinical management of brain tumours; we evaluated the
literature within the context of low-and-middle-income
country challenges. Circulating tumour cells (CTCs),
circulating tumour DNA (ctDNA), cell-free DNA (cfDNA),
extracellular vesicle-associated biomarkers, protein
biomarkers, microRNAs, and serum metabolites are
discussed with the collation of current data supporting
their utility in liquid biopsy. Further challenges to
implanting liquid biopsy tools at a systematic level are
highlighted.
Keywords: Tumour, DNA, Neoplastic Cells, Liquid
Biopsy, Brain Neoplasms, MicroRNAs, Extracellular
Vesicles
|
| format | Article |
| id | doaj-art-1c43568124d3457e85b0a6fbe690d8f4 |
| institution | Kabale University |
| issn | 0030-9982 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj-art-1c43568124d3457e85b0a6fbe690d8f42025-08-20T03:39:57ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822024-06-01743 (Supple)10.47391/JPMA.S3.GNO-06Serum liquid biopsy for brain tumours: a scoping analysis of practicable approaches in low- and middle-income countriesMohammad Hamza Bajwa0Muhammad Awais Khan1Faiza Urooj2Muhammad Usman Khalid3Syed Ather Enam4Hafiza Fatima Aziz5Kaynat Siddiqui6Muhammad Ehsan Bari7Nouman Mughal8Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.Khyber Medical College, Peshawar, Pakistan.Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan. Approaches to brain tumour diagnosis and detecting recurrence after treatment are costly and significantly invasive. Developing peripheral-sample liquid biopsy tools is the key to enhancing our ability to prognosticate brain tumour subtypes and molecular heterogeneity. The present scoping review was designed to discuss current updates in liquid biopsy tools for diagnosis and guiding clinical management of brain tumours; we evaluated the literature within the context of low-and-middle-income country challenges. Circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), cell-free DNA (cfDNA), extracellular vesicle-associated biomarkers, protein biomarkers, microRNAs, and serum metabolites are discussed with the collation of current data supporting their utility in liquid biopsy. Further challenges to implanting liquid biopsy tools at a systematic level are highlighted. Keywords: Tumour, DNA, Neoplastic Cells, Liquid Biopsy, Brain Neoplasms, MicroRNAs, Extracellular Vesicles https://jpma.org.pk/index.php/public_html/article/view/21165 |
| spellingShingle | Mohammad Hamza Bajwa Muhammad Awais Khan Faiza Urooj Muhammad Usman Khalid Syed Ather Enam Hafiza Fatima Aziz Kaynat Siddiqui Muhammad Ehsan Bari Nouman Mughal Serum liquid biopsy for brain tumours: a scoping analysis of practicable approaches in low- and middle-income countries Journal of the Pakistan Medical Association |
| title | Serum liquid biopsy for brain tumours: a scoping analysis of practicable approaches in low- and middle-income countries |
| title_full | Serum liquid biopsy for brain tumours: a scoping analysis of practicable approaches in low- and middle-income countries |
| title_fullStr | Serum liquid biopsy for brain tumours: a scoping analysis of practicable approaches in low- and middle-income countries |
| title_full_unstemmed | Serum liquid biopsy for brain tumours: a scoping analysis of practicable approaches in low- and middle-income countries |
| title_short | Serum liquid biopsy for brain tumours: a scoping analysis of practicable approaches in low- and middle-income countries |
| title_sort | serum liquid biopsy for brain tumours a scoping analysis of practicable approaches in low and middle income countries |
| url | https://jpma.org.pk/index.php/public_html/article/view/21165 |
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