Serum liquid biopsy for brain tumours: a scoping analysis of practicable approaches in low- and middle-income countries
Approaches to brain tumour diagnosis and detecting recurrence after treatment are costly and significantly invasive. Developing peripheral-sample liquid biopsy tools is the key to enhancing our ability to prognosticate brain tumour subtypes and molecular heterogeneity. The present scoping review wa...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pakistan Medical Association
2024-06-01
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| Series: | Journal of the Pakistan Medical Association |
| Online Access: | https://jpma.org.pk/index.php/public_html/article/view/21165 |
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| Summary: | Approaches to brain tumour diagnosis and detecting
recurrence after treatment are costly and significantly
invasive. Developing peripheral-sample liquid biopsy
tools is the key to enhancing our ability to prognosticate
brain tumour subtypes and molecular heterogeneity. The
present scoping review was designed to discuss current
updates in liquid biopsy tools for diagnosis and guiding
clinical management of brain tumours; we evaluated the
literature within the context of low-and-middle-income
country challenges. Circulating tumour cells (CTCs),
circulating tumour DNA (ctDNA), cell-free DNA (cfDNA),
extracellular vesicle-associated biomarkers, protein
biomarkers, microRNAs, and serum metabolites are
discussed with the collation of current data supporting
their utility in liquid biopsy. Further challenges to
implanting liquid biopsy tools at a systematic level are
highlighted.
Keywords: Tumour, DNA, Neoplastic Cells, Liquid
Biopsy, Brain Neoplasms, MicroRNAs, Extracellular
Vesicles
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| ISSN: | 0030-9982 |