Rapid Determination of Nimesulide by Capillary Zone Electrophoresis in Various Pharmaceutical Formulations
Nimesulide is a popular non-steroidal anti-inflammatory drug (NSAID) and a cyclooxygenase-2 inhibitor available in more than 50 countries worldwide. A rapid and simple method for nimesulide determination is presented. Experimental parameters based on a previously published work were revised and adop...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
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| Series: | Separations |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2297-8739/12/5/132 |
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| Summary: | Nimesulide is a popular non-steroidal anti-inflammatory drug (NSAID) and a cyclooxygenase-2 inhibitor available in more than 50 countries worldwide. A rapid and simple method for nimesulide determination is presented. Experimental parameters based on a previously published work were revised and adopted into a method with significantly better performance: pH was shifted from 8.10 to 9.25, borate background electrolyte concentration from 10 to 60 mM—resulting in a run time less than 4 min, and number of theoretical plates greater than 100,000. The method was validated and applied for the determination of nimesulide in three formulations with the active substance of nimesulide: tablets, gel, and powder (in sachets for oral suspension). Also, the tablets were tested for uniformity of content of single-dose preparations according to Ph. Eur. |
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| ISSN: | 2297-8739 |