The role of thrombophilia in the premature detachment of a normally located placenta
Aim: to study the association between hereditary/acquired thrombophilia and premature detachment of normally located placenta. Materials and methods. The participating women were divided into 2 groups: the main group (n = 38) and the control group (n = 43). The main group included women, whose pregn...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2019-05-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/550 |
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| author | N. M. Pasman O. V. Chumanova |
| author_facet | N. M. Pasman O. V. Chumanova |
| author_sort | N. M. Pasman |
| collection | DOAJ |
| description | Aim: to study the association between hereditary/acquired thrombophilia and premature detachment of normally located placenta. Materials and methods. The participating women were divided into 2 groups: the main group (n = 38) and the control group (n = 43). The main group included women, whose pregnancy or delivery was complicated by premature detachment of normally located placenta. The control group included women without previous obstetric or thrombotic complications, who gave birth to full-term live babies with an Apgar score of 8-10. The key coagulogram parameters, the presence of hyperhomocysteinemia, antiphospholipide syndrome, and polymorphisms of the hemostasis genes (by real-time polymerase chain reaction) were determined. Results. A statistically significant increase in the concentration of fibrinogen and D-dimer was found in patients of the main group. In addition, allele A of the G1691A polymorphic locus of the factor V gene and allele 4G of the 5G/4G 675 polymorphic locus of the PAI-1 gene are risk factors of placental detachment development. Conclusion. Hereditary and acquired thrombophilia are significant factors in the development of premature detachment of the normally located placenta. |
| format | Article |
| id | doaj-art-1c3f67e05cbb4465920ac87dd16ee6bf |
| institution | Kabale University |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2019-05-01 |
| publisher | IRBIS LLC |
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| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-1c3f67e05cbb4465920ac87dd16ee6bf2025-08-20T03:39:39ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942019-05-01131293410.17749/2313-7347.2019.13.1.029-034489The role of thrombophilia in the premature detachment of a normally located placentaN. M. Pasman0O. V. Chumanova1National Research Novosibirsk State University; Professor Pasman clinicNational Research Novosibirsk State UniversityAim: to study the association between hereditary/acquired thrombophilia and premature detachment of normally located placenta. Materials and methods. The participating women were divided into 2 groups: the main group (n = 38) and the control group (n = 43). The main group included women, whose pregnancy or delivery was complicated by premature detachment of normally located placenta. The control group included women without previous obstetric or thrombotic complications, who gave birth to full-term live babies with an Apgar score of 8-10. The key coagulogram parameters, the presence of hyperhomocysteinemia, antiphospholipide syndrome, and polymorphisms of the hemostasis genes (by real-time polymerase chain reaction) were determined. Results. A statistically significant increase in the concentration of fibrinogen and D-dimer was found in patients of the main group. In addition, allele A of the G1691A polymorphic locus of the factor V gene and allele 4G of the 5G/4G 675 polymorphic locus of the PAI-1 gene are risk factors of placental detachment development. Conclusion. Hereditary and acquired thrombophilia are significant factors in the development of premature detachment of the normally located placenta.https://www.gynecology.su/jour/article/view/550normally located placentapremature detachmenthereditarythrombophiliaacquired thrombophiliahypercoagulation |
| spellingShingle | N. M. Pasman O. V. Chumanova The role of thrombophilia in the premature detachment of a normally located placenta Акушерство, гинекология и репродукция normally located placenta premature detachment hereditarythrombophilia acquired thrombophilia hypercoagulation |
| title | The role of thrombophilia in the premature detachment of a normally located placenta |
| title_full | The role of thrombophilia in the premature detachment of a normally located placenta |
| title_fullStr | The role of thrombophilia in the premature detachment of a normally located placenta |
| title_full_unstemmed | The role of thrombophilia in the premature detachment of a normally located placenta |
| title_short | The role of thrombophilia in the premature detachment of a normally located placenta |
| title_sort | role of thrombophilia in the premature detachment of a normally located placenta |
| topic | normally located placenta premature detachment hereditarythrombophilia acquired thrombophilia hypercoagulation |
| url | https://www.gynecology.su/jour/article/view/550 |
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