Syphilis and Urogenital Diseases during Pregnancy and Developmental Defects of Enamel: A Brazilian Prenatal Cohort (BRISA)
Objective: To evaluate the effect of syphilis and urogenital diseases (SUD) during pregnancy on developmental defects of enamel (DDE) using causal inference models. Material and Methods: This study is a prospective cohort – the Brazilian Ribeirão Preto and São Luís Cohort Study (BRISA) – including...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Association of Support to Oral Health Research (APESB)
2025-02-01
|
| Series: | Pesquisa Brasileira em Odontopediatria e Clínica Integrada |
| Subjects: | |
| Online Access: | https://revista.uepb.edu.br/PBOCI/article/view/4296 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823858678263971840 |
|---|---|
| author | Elisa Miranda Costa Judith Rafaelle Oliveira Pinho Maria da Conceição Pereira Saraiva Cecília Cláudia Costa Ribeiro Claudia Maria Coêlho Alves Erika Barbara Abreu Fonseca Thomaz |
| author_facet | Elisa Miranda Costa Judith Rafaelle Oliveira Pinho Maria da Conceição Pereira Saraiva Cecília Cláudia Costa Ribeiro Claudia Maria Coêlho Alves Erika Barbara Abreu Fonseca Thomaz |
| author_sort | Elisa Miranda Costa |
| collection | DOAJ |
| description |
Objective: To evaluate the effect of syphilis and urogenital diseases (SUD) during pregnancy on developmental defects of enamel (DDE) using causal inference models. Material and Methods: This study is a prospective cohort – the Brazilian Ribeirão Preto and São Luís Cohort Study (BRISA) – including 865 mother-child dyads, evaluated in three moments: prenatal care (22nd and 25th weeks of gestational age); baby birth; and between 12.3-36 months of age. The outcome was assessed according to the modified DDE index. The exposition, SUD, comprised at least one of the following infections: bacterial vaginosis, urinary tract infection, and syphilis. The covariables included in the theoretical model were socioeconomic situation (SES), low birth weight, mother’s age, number of prenatal care visits (PCV), hypertension, diabetes, medication use during pregnancy, and child’s age. Based on the proposed directed acyclic graph (DAG), SES and the number of PCV were the minimal set of covariables for the adjusted model. The effects were estimated by causal inference using a marginal structural model (Average Treatment Effect - ATE coefficients). Results: SUD did not interfere in the incidence of DDE (ATE: -0.92; CI95%: -0.23-0.49; p=0.202). Conclusion: SUD during pregnancy does not have a causal effect on DDE on primary dentition. Another possibility is that other infections not included in the model may have confounded the association, biasing toward the null hypothesis.
|
| format | Article |
| id | doaj-art-1c3a8b935f9e4759b6c87172a06345f2 |
| institution | Kabale University |
| issn | 1519-0501 1983-4632 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Association of Support to Oral Health Research (APESB) |
| record_format | Article |
| series | Pesquisa Brasileira em Odontopediatria e Clínica Integrada |
| spelling | doaj-art-1c3a8b935f9e4759b6c87172a06345f22025-02-11T10:28:51ZengAssociation of Support to Oral Health Research (APESB)Pesquisa Brasileira em Odontopediatria e Clínica Integrada1519-05011983-46322025-02-0125Syphilis and Urogenital Diseases during Pregnancy and Developmental Defects of Enamel: A Brazilian Prenatal Cohort (BRISA)Elisa Miranda CostaJudith Rafaelle Oliveira PinhoMaria da Conceição Pereira SaraivaCecília Cláudia Costa RibeiroClaudia Maria Coêlho AlvesErika Barbara Abreu Fonseca Thomaz Objective: To evaluate the effect of syphilis and urogenital diseases (SUD) during pregnancy on developmental defects of enamel (DDE) using causal inference models. Material and Methods: This study is a prospective cohort – the Brazilian Ribeirão Preto and São Luís Cohort Study (BRISA) – including 865 mother-child dyads, evaluated in three moments: prenatal care (22nd and 25th weeks of gestational age); baby birth; and between 12.3-36 months of age. The outcome was assessed according to the modified DDE index. The exposition, SUD, comprised at least one of the following infections: bacterial vaginosis, urinary tract infection, and syphilis. The covariables included in the theoretical model were socioeconomic situation (SES), low birth weight, mother’s age, number of prenatal care visits (PCV), hypertension, diabetes, medication use during pregnancy, and child’s age. Based on the proposed directed acyclic graph (DAG), SES and the number of PCV were the minimal set of covariables for the adjusted model. The effects were estimated by causal inference using a marginal structural model (Average Treatment Effect - ATE coefficients). Results: SUD did not interfere in the incidence of DDE (ATE: -0.92; CI95%: -0.23-0.49; p=0.202). Conclusion: SUD during pregnancy does not have a causal effect on DDE on primary dentition. Another possibility is that other infections not included in the model may have confounded the association, biasing toward the null hypothesis. https://revista.uepb.edu.br/PBOCI/article/view/4296Developmental Defects of EnamelEpidemiologic MethodsPregnant PeopleInfections |
| spellingShingle | Elisa Miranda Costa Judith Rafaelle Oliveira Pinho Maria da Conceição Pereira Saraiva Cecília Cláudia Costa Ribeiro Claudia Maria Coêlho Alves Erika Barbara Abreu Fonseca Thomaz Syphilis and Urogenital Diseases during Pregnancy and Developmental Defects of Enamel: A Brazilian Prenatal Cohort (BRISA) Pesquisa Brasileira em Odontopediatria e Clínica Integrada Developmental Defects of Enamel Epidemiologic Methods Pregnant People Infections |
| title | Syphilis and Urogenital Diseases during Pregnancy and Developmental Defects of Enamel: A Brazilian Prenatal Cohort (BRISA) |
| title_full | Syphilis and Urogenital Diseases during Pregnancy and Developmental Defects of Enamel: A Brazilian Prenatal Cohort (BRISA) |
| title_fullStr | Syphilis and Urogenital Diseases during Pregnancy and Developmental Defects of Enamel: A Brazilian Prenatal Cohort (BRISA) |
| title_full_unstemmed | Syphilis and Urogenital Diseases during Pregnancy and Developmental Defects of Enamel: A Brazilian Prenatal Cohort (BRISA) |
| title_short | Syphilis and Urogenital Diseases during Pregnancy and Developmental Defects of Enamel: A Brazilian Prenatal Cohort (BRISA) |
| title_sort | syphilis and urogenital diseases during pregnancy and developmental defects of enamel a brazilian prenatal cohort brisa |
| topic | Developmental Defects of Enamel Epidemiologic Methods Pregnant People Infections |
| url | https://revista.uepb.edu.br/PBOCI/article/view/4296 |
| work_keys_str_mv | AT elisamirandacosta syphilisandurogenitaldiseasesduringpregnancyanddevelopmentaldefectsofenamelabrazilianprenatalcohortbrisa AT judithrafaelleoliveirapinho syphilisandurogenitaldiseasesduringpregnancyanddevelopmentaldefectsofenamelabrazilianprenatalcohortbrisa AT mariadaconceicaopereirasaraiva syphilisandurogenitaldiseasesduringpregnancyanddevelopmentaldefectsofenamelabrazilianprenatalcohortbrisa AT ceciliaclaudiacostaribeiro syphilisandurogenitaldiseasesduringpregnancyanddevelopmentaldefectsofenamelabrazilianprenatalcohortbrisa AT claudiamariacoelhoalves syphilisandurogenitaldiseasesduringpregnancyanddevelopmentaldefectsofenamelabrazilianprenatalcohortbrisa AT erikabarbaraabreufonsecathomaz syphilisandurogenitaldiseasesduringpregnancyanddevelopmentaldefectsofenamelabrazilianprenatalcohortbrisa |