RTEL1 is upregulated in gastric cancer and promotes tumor growth
Abstract Gastric cancer (GC) is one of the most common cancers worldwide, with increasing incidence and mortality rates. It is typically diagnosed at advanced stages, leading to a poor prognosis. GC is a highly heterogeneous disease and its progression is associated with complex interplay between ge...
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| Format: | Article |
| Language: | English |
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Springer
2024-12-01
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| Series: | Journal of Cancer Research and Clinical Oncology |
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| Online Access: | https://doi.org/10.1007/s00432-024-06062-0 |
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| _version_ | 1823863250998001664 |
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| author | Chunyu Yang Suzeng Wang Ge Gao Peiwen Xu Mengyuan Qian Yuan Yin Surui Yao Zhaohui Huang Zehua Bian |
| author_facet | Chunyu Yang Suzeng Wang Ge Gao Peiwen Xu Mengyuan Qian Yuan Yin Surui Yao Zhaohui Huang Zehua Bian |
| author_sort | Chunyu Yang |
| collection | DOAJ |
| description | Abstract Gastric cancer (GC) is one of the most common cancers worldwide, with increasing incidence and mortality rates. It is typically diagnosed at advanced stages, leading to a poor prognosis. GC is a highly heterogeneous disease and its progression is associated with complex interplay between genetic and environmental factors. Identifying novel genes and pathways involved in GC development is crucial for improving the therapeutic outcome. Regulator of Telomerase Length 1 (RTEL1) has been found to maintain telomere stability through its helicase activity, facilitating telomere reconstruction and repair. However, the precise role of RTEL1 in human cancers, particularly in GC, is not yet fully understood. In this study, we observed significantly increased RTEL1 expression in GC tissues, which was associated with a poor prognosis. Functionally, RTEL1 promotes GC cell proliferation both in vitro and in vivo. Additionally, RTEL1 appears to regulate multiple signaling pathways, with a particular promoting effect on the cell cycle progression. Notably, CDC23 and TRIP13 are potential downstream target genes of RTEL1, which may mediate its tumor-promoting effects in GC. These findings suggest that RTEL1 plays a critical role in GC tumorigenesis and could be a promising target for the therapy and prognosis of GC. |
| format | Article |
| id | doaj-art-1c35a6c8594641c383fcc4a842b83b59 |
| institution | Kabale University |
| issn | 1432-1335 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-1c35a6c8594641c383fcc4a842b83b592025-02-09T12:10:13ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352024-12-01151111010.1007/s00432-024-06062-0RTEL1 is upregulated in gastric cancer and promotes tumor growthChunyu Yang0Suzeng Wang1Ge Gao2Peiwen Xu3Mengyuan Qian4Yuan Yin5Surui Yao6Zhaohui Huang7Zehua Bian8Wuxi Cancer Institute, Affiliated Hospital of Jiangnan UniversityWuxi Cancer Institute, Affiliated Hospital of Jiangnan UniversityWuxi Cancer Institute, Affiliated Hospital of Jiangnan UniversityWuxi Cancer Institute, Affiliated Hospital of Jiangnan UniversityWuxi Cancer Institute, Affiliated Hospital of Jiangnan UniversityWuxi Cancer Institute, Affiliated Hospital of Jiangnan UniversityWuxi Cancer Institute, Affiliated Hospital of Jiangnan UniversityWuxi Cancer Institute, Affiliated Hospital of Jiangnan UniversityWuxi Cancer Institute, Affiliated Hospital of Jiangnan UniversityAbstract Gastric cancer (GC) is one of the most common cancers worldwide, with increasing incidence and mortality rates. It is typically diagnosed at advanced stages, leading to a poor prognosis. GC is a highly heterogeneous disease and its progression is associated with complex interplay between genetic and environmental factors. Identifying novel genes and pathways involved in GC development is crucial for improving the therapeutic outcome. Regulator of Telomerase Length 1 (RTEL1) has been found to maintain telomere stability through its helicase activity, facilitating telomere reconstruction and repair. However, the precise role of RTEL1 in human cancers, particularly in GC, is not yet fully understood. In this study, we observed significantly increased RTEL1 expression in GC tissues, which was associated with a poor prognosis. Functionally, RTEL1 promotes GC cell proliferation both in vitro and in vivo. Additionally, RTEL1 appears to regulate multiple signaling pathways, with a particular promoting effect on the cell cycle progression. Notably, CDC23 and TRIP13 are potential downstream target genes of RTEL1, which may mediate its tumor-promoting effects in GC. These findings suggest that RTEL1 plays a critical role in GC tumorigenesis and could be a promising target for the therapy and prognosis of GC.https://doi.org/10.1007/s00432-024-06062-0Gastric cancerRTEL1Cell cycleTumor proliferationCDC23TRIP13 |
| spellingShingle | Chunyu Yang Suzeng Wang Ge Gao Peiwen Xu Mengyuan Qian Yuan Yin Surui Yao Zhaohui Huang Zehua Bian RTEL1 is upregulated in gastric cancer and promotes tumor growth Journal of Cancer Research and Clinical Oncology Gastric cancer RTEL1 Cell cycle Tumor proliferation CDC23 TRIP13 |
| title | RTEL1 is upregulated in gastric cancer and promotes tumor growth |
| title_full | RTEL1 is upregulated in gastric cancer and promotes tumor growth |
| title_fullStr | RTEL1 is upregulated in gastric cancer and promotes tumor growth |
| title_full_unstemmed | RTEL1 is upregulated in gastric cancer and promotes tumor growth |
| title_short | RTEL1 is upregulated in gastric cancer and promotes tumor growth |
| title_sort | rtel1 is upregulated in gastric cancer and promotes tumor growth |
| topic | Gastric cancer RTEL1 Cell cycle Tumor proliferation CDC23 TRIP13 |
| url | https://doi.org/10.1007/s00432-024-06062-0 |
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