Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents
Objective. To assess the long-term effects of metformin in combination with lifestyle intervention and its association between insulin levels and the degree of steatosis at ultrasonography (US) in obese adolescents. Methods. Thirty-five postpubertal obese boys were randomized into two groups: one re...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2010/831901 |
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| author | Lian Tock Ana R. Dâmaso Aline de Piano June Carnier Priscila L. Sanches Henrique Manoel Lederman Regina M. Y. Ernandes Marco Túlio de Mello Sérgio Tufik |
| author_facet | Lian Tock Ana R. Dâmaso Aline de Piano June Carnier Priscila L. Sanches Henrique Manoel Lederman Regina M. Y. Ernandes Marco Túlio de Mello Sérgio Tufik |
| author_sort | Lian Tock |
| collection | DOAJ |
| description | Objective. To assess the long-term effects of metformin in combination with lifestyle intervention and its association between insulin levels and the degree of steatosis at ultrasonography (US) in obese adolescents. Methods. Thirty-five postpubertal obese boys were randomized into two groups: one receiving metformin in combination with a multidisciplinary lifestyle intervention versus a placebo group, which also received the same intervention. The visceral, subcutaneous fat and degree of steatosis were measured by ultrasonography. Fasting blood samples were collected to analyze glucose, insulin, insulin resistance, and aminotransferases. Repeated ANOVA measures were used to compare changes over time and between groups, and Spearman's correlations were used to identify an association between insulin and the degree of steatosis at US. Results. There was a positive correlation between the degree of steatosis at US with insulin concentrations and HOMA-IR. Long-term therapy plus metformin significantly reduced body weight, body mass index, insulin, HOMA-IR, and visceral fat. Conclusions. Metformin was more effective than the placebo in improving clinical parameters associated with obesity and steatosis. |
| format | Article |
| id | doaj-art-1c3550026abc49289b1c14591dcbd9fe |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-1c3550026abc49289b1c14591dcbd9fe2025-02-03T05:59:34ZengWileyJournal of Obesity2090-07082090-07162010-01-01201010.1155/2010/831901831901Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese AdolescentsLian Tock0Ana R. Dâmaso1Aline de Piano2June Carnier3Priscila L. Sanches4Henrique Manoel Lederman5Regina M. Y. Ernandes6Marco Túlio de Mello7Sérgio Tufik8Post Graduate Program of Nutrition, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, BrazilPost Graduate Program of Nutrition, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, BrazilPost Graduate Program of Nutrition, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, BrazilPost Graduate Program of Nutrition, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, BrazilPost Graduate Program of Nutrition, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, BrazilImaging Diagnostic, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, BrazilAssociation Found of Incentive to Physicobiology, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, BrazilAssociation Found of Incentive to Physicobiology, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, BrazilAssociation Found of Incentive to Physicobiology, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, BrazilObjective. To assess the long-term effects of metformin in combination with lifestyle intervention and its association between insulin levels and the degree of steatosis at ultrasonography (US) in obese adolescents. Methods. Thirty-five postpubertal obese boys were randomized into two groups: one receiving metformin in combination with a multidisciplinary lifestyle intervention versus a placebo group, which also received the same intervention. The visceral, subcutaneous fat and degree of steatosis were measured by ultrasonography. Fasting blood samples were collected to analyze glucose, insulin, insulin resistance, and aminotransferases. Repeated ANOVA measures were used to compare changes over time and between groups, and Spearman's correlations were used to identify an association between insulin and the degree of steatosis at US. Results. There was a positive correlation between the degree of steatosis at US with insulin concentrations and HOMA-IR. Long-term therapy plus metformin significantly reduced body weight, body mass index, insulin, HOMA-IR, and visceral fat. Conclusions. Metformin was more effective than the placebo in improving clinical parameters associated with obesity and steatosis.http://dx.doi.org/10.1155/2010/831901 |
| spellingShingle | Lian Tock Ana R. Dâmaso Aline de Piano June Carnier Priscila L. Sanches Henrique Manoel Lederman Regina M. Y. Ernandes Marco Túlio de Mello Sérgio Tufik Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents Journal of Obesity |
| title | Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents |
| title_full | Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents |
| title_fullStr | Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents |
| title_full_unstemmed | Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents |
| title_short | Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents |
| title_sort | long term effects of metformin and lifestyle modification on nonalcoholic fatty liver disease obese adolescents |
| url | http://dx.doi.org/10.1155/2010/831901 |
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