Prevalence of Atopobium vaginae and Porphyromonas somerae in the Genital Tract of Women Undergoing Hysterectomy for Benign and Malignant Disease at a South Indian Tertiary Hospital
Background: Endometrial cancer is the third most common cancer affecting the lower genital tract of women. Studies have shown modifiable and nonmodifiable risk factors for the same, which include genetic factors and microbes. Alteration in the microflora of the lower genital tract might be a trigger...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Mid-Life Health |
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| Online Access: | https://journals.lww.com/10.4103/jmh.jmh_165_24 |
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| author | Vinodhini Kadirvel D. Jayalakshmi Rakesh Singh P. Veena |
| author_facet | Vinodhini Kadirvel D. Jayalakshmi Rakesh Singh P. Veena |
| author_sort | Vinodhini Kadirvel |
| collection | DOAJ |
| description | Background:
Endometrial cancer is the third most common cancer affecting the lower genital tract of women. Studies have shown modifiable and nonmodifiable risk factors for the same, which include genetic factors and microbes. Alteration in the microflora of the lower genital tract might be a triggering factor for many pathological and malignant conditions. Hence, we tried to explore the occurrence of Atopobium vaginae and Porphyromonas somerae in the lower genital tract of women with endometrial cancer and the factors associated with them.
Materials and Methods:
The study enrolled 64 patients aged between 40 and 80 years, of which 32 cases were cases of endometrial cancer and 32 cases had benign gynecological diseases. After taking the history and demographic profile of the patients, three swabs from the cervix and vagina were sent for gram staining, culture with blood and MacConkey agar, and antibiotic susceptibility tests. A real-time polymerase chain reaction was also done for molecular identification of organisms.
Results:
Around 50% of women with endometrial cancer had isolated colonization with A. vaginae and P. somerae, with 25% showing the coexistence of both the organisms, whereas the benign gynecological disease group displayed absence of any organisms in 56% of women.
Conclusion:
Coexistence of A. vaginae and P. somerae in the lower genital tract showed a significantly higher occurrence of endometrial cancer in comparison to those having either only one. |
| format | Article |
| id | doaj-art-1c2ee1233eb9443ca7948bc89c950a6a |
| institution | Kabale University |
| issn | 0976-7800 0976-7819 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Mid-Life Health |
| spelling | doaj-art-1c2ee1233eb9443ca7948bc89c950a6a2025-08-20T03:48:52ZengWolters Kluwer Medknow PublicationsJournal of Mid-Life Health0976-78000976-78192025-01-01161919510.4103/jmh.jmh_165_24Prevalence of Atopobium vaginae and Porphyromonas somerae in the Genital Tract of Women Undergoing Hysterectomy for Benign and Malignant Disease at a South Indian Tertiary HospitalVinodhini KadirvelD. JayalakshmiRakesh SinghP. VeenaBackground: Endometrial cancer is the third most common cancer affecting the lower genital tract of women. Studies have shown modifiable and nonmodifiable risk factors for the same, which include genetic factors and microbes. Alteration in the microflora of the lower genital tract might be a triggering factor for many pathological and malignant conditions. Hence, we tried to explore the occurrence of Atopobium vaginae and Porphyromonas somerae in the lower genital tract of women with endometrial cancer and the factors associated with them. Materials and Methods: The study enrolled 64 patients aged between 40 and 80 years, of which 32 cases were cases of endometrial cancer and 32 cases had benign gynecological diseases. After taking the history and demographic profile of the patients, three swabs from the cervix and vagina were sent for gram staining, culture with blood and MacConkey agar, and antibiotic susceptibility tests. A real-time polymerase chain reaction was also done for molecular identification of organisms. Results: Around 50% of women with endometrial cancer had isolated colonization with A. vaginae and P. somerae, with 25% showing the coexistence of both the organisms, whereas the benign gynecological disease group displayed absence of any organisms in 56% of women. Conclusion: Coexistence of A. vaginae and P. somerae in the lower genital tract showed a significantly higher occurrence of endometrial cancer in comparison to those having either only one.https://journals.lww.com/10.4103/jmh.jmh_165_24atopobium vaginaeendometrial cancergenital tractgynecologyporphyromonas somerae |
| spellingShingle | Vinodhini Kadirvel D. Jayalakshmi Rakesh Singh P. Veena Prevalence of Atopobium vaginae and Porphyromonas somerae in the Genital Tract of Women Undergoing Hysterectomy for Benign and Malignant Disease at a South Indian Tertiary Hospital Journal of Mid-Life Health atopobium vaginae endometrial cancer genital tract gynecology porphyromonas somerae |
| title | Prevalence of Atopobium vaginae and Porphyromonas somerae in the Genital Tract of Women Undergoing Hysterectomy for Benign and Malignant Disease at a South Indian Tertiary Hospital |
| title_full | Prevalence of Atopobium vaginae and Porphyromonas somerae in the Genital Tract of Women Undergoing Hysterectomy for Benign and Malignant Disease at a South Indian Tertiary Hospital |
| title_fullStr | Prevalence of Atopobium vaginae and Porphyromonas somerae in the Genital Tract of Women Undergoing Hysterectomy for Benign and Malignant Disease at a South Indian Tertiary Hospital |
| title_full_unstemmed | Prevalence of Atopobium vaginae and Porphyromonas somerae in the Genital Tract of Women Undergoing Hysterectomy for Benign and Malignant Disease at a South Indian Tertiary Hospital |
| title_short | Prevalence of Atopobium vaginae and Porphyromonas somerae in the Genital Tract of Women Undergoing Hysterectomy for Benign and Malignant Disease at a South Indian Tertiary Hospital |
| title_sort | prevalence of atopobium vaginae and porphyromonas somerae in the genital tract of women undergoing hysterectomy for benign and malignant disease at a south indian tertiary hospital |
| topic | atopobium vaginae endometrial cancer genital tract gynecology porphyromonas somerae |
| url | https://journals.lww.com/10.4103/jmh.jmh_165_24 |
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