In silico construction of polyvalent multi-epitope respiratory syncytial virus subunit vaccine: focusing on prevalent HLA allele types in Korea
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory infections in infants and the elderly. The burden of RSV-related hospitalizations and deaths is significantly increasing. Recently, RSV vaccines targeting F protein have been approved, but their long-term efficacy is yet to be...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Journal of Taibah University for Science |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/16583655.2025.2514284 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850224733553950720 |
|---|---|
| author | Myoung Hee Han Bomi Yoon Min-Kyu Kim Seonghee Park Jae Hyang Lim |
| author_facet | Myoung Hee Han Bomi Yoon Min-Kyu Kim Seonghee Park Jae Hyang Lim |
| author_sort | Myoung Hee Han |
| collection | DOAJ |
| description | Respiratory syncytial virus (RSV) is a leading cause of lower respiratory infections in infants and the elderly. The burden of RSV-related hospitalizations and deaths is significantly increasing. Recently, RSV vaccines targeting F protein have been approved, but their long-term efficacy is yet to be evaluated. This study aimed to design a polyvalent multi-epitope RSV subunit vaccine tailored to Korean HLA types using in silico methods. Nine prevalent HLA allele types in Korea were used to predict vaccine epitopes. Combinations of selected epitopes were created, and stable combinations were selected and conjugated with human β-defensin and PADRE. Fifty-five multi-epitope combinations were selected for vaccine construction, and 33 vaccine constructs induced strong immune responses in silico. The final vaccine candidate is a 228-amino acid construct weighing 23,957 Da and effectively induces humoral and cellular immune responses with high population coverage, suggesting potential for further development. |
| format | Article |
| id | doaj-art-1c2a24c478b146d5bd1fe00d6477f002 |
| institution | OA Journals |
| issn | 1658-3655 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Taibah University for Science |
| spelling | doaj-art-1c2a24c478b146d5bd1fe00d6477f0022025-08-20T02:05:32ZengTaylor & Francis GroupJournal of Taibah University for Science1658-36552025-12-0119110.1080/16583655.2025.2514284In silico construction of polyvalent multi-epitope respiratory syncytial virus subunit vaccine: focusing on prevalent HLA allele types in KoreaMyoung Hee Han0Bomi Yoon1Min-Kyu Kim2Seonghee Park3Jae Hyang Lim4Department of Microbiology, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaDepartment of Microbiology, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaAdvanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Republic of KoreaDepartment of Physiology, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaDepartment of Microbiology, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaRespiratory syncytial virus (RSV) is a leading cause of lower respiratory infections in infants and the elderly. The burden of RSV-related hospitalizations and deaths is significantly increasing. Recently, RSV vaccines targeting F protein have been approved, but their long-term efficacy is yet to be evaluated. This study aimed to design a polyvalent multi-epitope RSV subunit vaccine tailored to Korean HLA types using in silico methods. Nine prevalent HLA allele types in Korea were used to predict vaccine epitopes. Combinations of selected epitopes were created, and stable combinations were selected and conjugated with human β-defensin and PADRE. Fifty-five multi-epitope combinations were selected for vaccine construction, and 33 vaccine constructs induced strong immune responses in silico. The final vaccine candidate is a 228-amino acid construct weighing 23,957 Da and effectively induces humoral and cellular immune responses with high population coverage, suggesting potential for further development.https://www.tandfonline.com/doi/10.1080/16583655.2025.2514284Respiratory syncytial virusmultiepitopein silicorecombinant subunit vaccine |
| spellingShingle | Myoung Hee Han Bomi Yoon Min-Kyu Kim Seonghee Park Jae Hyang Lim In silico construction of polyvalent multi-epitope respiratory syncytial virus subunit vaccine: focusing on prevalent HLA allele types in Korea Journal of Taibah University for Science Respiratory syncytial virus multiepitope in silico recombinant subunit vaccine |
| title | In silico construction of polyvalent multi-epitope respiratory syncytial virus subunit vaccine: focusing on prevalent HLA allele types in Korea |
| title_full | In silico construction of polyvalent multi-epitope respiratory syncytial virus subunit vaccine: focusing on prevalent HLA allele types in Korea |
| title_fullStr | In silico construction of polyvalent multi-epitope respiratory syncytial virus subunit vaccine: focusing on prevalent HLA allele types in Korea |
| title_full_unstemmed | In silico construction of polyvalent multi-epitope respiratory syncytial virus subunit vaccine: focusing on prevalent HLA allele types in Korea |
| title_short | In silico construction of polyvalent multi-epitope respiratory syncytial virus subunit vaccine: focusing on prevalent HLA allele types in Korea |
| title_sort | in silico construction of polyvalent multi epitope respiratory syncytial virus subunit vaccine focusing on prevalent hla allele types in korea |
| topic | Respiratory syncytial virus multiepitope in silico recombinant subunit vaccine |
| url | https://www.tandfonline.com/doi/10.1080/16583655.2025.2514284 |
| work_keys_str_mv | AT myoungheehan insilicoconstructionofpolyvalentmultiepitoperespiratorysyncytialvirussubunitvaccinefocusingonprevalenthlaalleletypesinkorea AT bomiyoon insilicoconstructionofpolyvalentmultiepitoperespiratorysyncytialvirussubunitvaccinefocusingonprevalenthlaalleletypesinkorea AT minkyukim insilicoconstructionofpolyvalentmultiepitoperespiratorysyncytialvirussubunitvaccinefocusingonprevalenthlaalleletypesinkorea AT seongheepark insilicoconstructionofpolyvalentmultiepitoperespiratorysyncytialvirussubunitvaccinefocusingonprevalenthlaalleletypesinkorea AT jaehyanglim insilicoconstructionofpolyvalentmultiepitoperespiratorysyncytialvirussubunitvaccinefocusingonprevalenthlaalleletypesinkorea |