Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases
Liver metastases of colorectal cancer can be operated with a curative intent in selected cases. However, more than half of the patients have a recurrence. The aim of this study was to evaluate the prognostic and predictive value of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9),...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-01-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317752944 |
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| author | Reetta Peltonen Pia Österlund Marko Lempinen Arno Nordin Ulf-Håkan Stenman Helena Isoniemi |
| author_facet | Reetta Peltonen Pia Österlund Marko Lempinen Arno Nordin Ulf-Håkan Stenman Helena Isoniemi |
| author_sort | Reetta Peltonen |
| collection | DOAJ |
| description | Liver metastases of colorectal cancer can be operated with a curative intent in selected cases. However, more than half of the patients have a recurrence. The aim of this study was to evaluate the prognostic and predictive value of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), human chorionic gonadotropin β (hCGβ) and tumour-associated trypsin-inhibitor (TATI) in colorectal cancer patients before and 3 months after resection of liver metastases. Marker concentrations were determined in blood samples from 168 colorectal cancer patients, who underwent liver resection between the years 1998 and 2007 at Helsinki University Hospital, Finland. The samples were taken before and 3 months after curative resection. Increased concentrations of CEA (>5 µg/L) and hCGβ (>1 pmol/L) 3 months after liver resection correlated with recurrence and impaired overall survival and increased CA19-9 (>26 kU/L) with impaired overall survival, but postoperative TATI was not prognostic. Preoperatively elevated CEA and CA19-9 correlated with impaired overall survival, but not with recurrence. Neither preoperative hCGβ nor TATI was prognostic. In conclusion, CEA is a useful prognostic marker, when measured 3 months after resection of colorectal liver metastases. CA19-9 also has prognostic significance and may have additional value. |
| format | Article |
| id | doaj-art-1c2a1493b4314e6c95e69a5fc3eb02fc |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-1c2a1493b4314e6c95e69a5fc3eb02fc2025-08-20T03:33:18ZengSAGE PublishingTumor Biology1423-03802018-01-014010.1177/1010428317752944Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastasesReetta Peltonen0Pia Österlund1Marko Lempinen2Arno Nordin3Ulf-Håkan Stenman4Helena Isoniemi5Faculty of Medicine and Doctoral Programme in Clinical Research, University of Helsinki, Helsinki, FinlandInstitute of Clinical Medicine, University of Helsinki, Helsinki, FinlandTransplantation and Liver Surgery Clinic, Helsinki University Hospital, Helsinki, FinlandTransplantation and Liver Surgery Clinic, Helsinki University Hospital, Helsinki, FinlandDepartment of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandInstitute of Clinical Medicine, University of Helsinki, Helsinki, FinlandLiver metastases of colorectal cancer can be operated with a curative intent in selected cases. However, more than half of the patients have a recurrence. The aim of this study was to evaluate the prognostic and predictive value of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), human chorionic gonadotropin β (hCGβ) and tumour-associated trypsin-inhibitor (TATI) in colorectal cancer patients before and 3 months after resection of liver metastases. Marker concentrations were determined in blood samples from 168 colorectal cancer patients, who underwent liver resection between the years 1998 and 2007 at Helsinki University Hospital, Finland. The samples were taken before and 3 months after curative resection. Increased concentrations of CEA (>5 µg/L) and hCGβ (>1 pmol/L) 3 months after liver resection correlated with recurrence and impaired overall survival and increased CA19-9 (>26 kU/L) with impaired overall survival, but postoperative TATI was not prognostic. Preoperatively elevated CEA and CA19-9 correlated with impaired overall survival, but not with recurrence. Neither preoperative hCGβ nor TATI was prognostic. In conclusion, CEA is a useful prognostic marker, when measured 3 months after resection of colorectal liver metastases. CA19-9 also has prognostic significance and may have additional value.https://doi.org/10.1177/1010428317752944 |
| spellingShingle | Reetta Peltonen Pia Österlund Marko Lempinen Arno Nordin Ulf-Håkan Stenman Helena Isoniemi Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases Tumor Biology |
| title | Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases |
| title_full | Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases |
| title_fullStr | Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases |
| title_full_unstemmed | Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases |
| title_short | Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases |
| title_sort | postoperative cea is a better prognostic marker than ca19 9 hcgβ or tati after resection of colorectal liver metastases |
| url | https://doi.org/10.1177/1010428317752944 |
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