Assessment of myeloid response and iron status among Sudanese pediatric ESKD on hemodialysis through reticulocyte parameters and β-globin mRNA expression

Assessment of myeloid response and iron status among Sudanese pediatric ESKD on hemodialysis through reticulocyte parameters and β-globin mRNA expression

Abstract Background Sudanese children with End-Stage Kidney Disease (ESKD) often show limited improvement in hemoglobin levels despite treatment with recombinant human erythropoietin (rHuEPO). This study aims to assess the response to rHuEPO therapy by analyzing β-globin mRNA expression and reticulo...

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Main Authors: Abier Abdelaziz Makkawi Abdelrahman, Ahmed Ibrahim Marzouk, Osama Ali Altayeb, Eman Abbas Fadul, Mugtaba Osman, Nahla Allam, Nadia Madani Mohammed Ahmed, Nazik Elmalaika Obaid Seid Ahmed Husain
Format: Article
Language:English
Published: BMC 2024-10-01
Series:BMC Nephrology
Subjects:
β-globin mRNA expression
End-stage kidney disease (ESKD)
Ferritin
Flow cytometry
Hypochromic cells (HYPO%)
Immature reticulocyte fraction (IRF)
Online Access:https://doi.org/10.1186/s12882-024-03806-5
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