Inhalable liposomal delivery of osimertinib and DNA for treating primary and metastasis lung cancer
Abstract Lung cancer remains one of the most common malignancies, and its brain metastases significantly worsen the prognosis for patients. Current treatments for lung cancer face many challenges, including poor drug accumulation and the inability to simultaneously control primary and metastatic tum...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58312-5 |
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| author | Xianglei Fu Yanbin Shi Hang Wu Yankun Zhang Yingying Liu Xiaoyu Wan Xiangqin Chen Jiamin Zhou Shengnan Qiu Xiaogang Zhao Zhongxian Tian Lian Li Hengchang Zang Guimei Lin |
| author_facet | Xianglei Fu Yanbin Shi Hang Wu Yankun Zhang Yingying Liu Xiaoyu Wan Xiangqin Chen Jiamin Zhou Shengnan Qiu Xiaogang Zhao Zhongxian Tian Lian Li Hengchang Zang Guimei Lin |
| author_sort | Xianglei Fu |
| collection | DOAJ |
| description | Abstract Lung cancer remains one of the most common malignancies, and its brain metastases significantly worsen the prognosis for patients. Current treatments for lung cancer face many challenges, including poor drug accumulation and the inability to simultaneously control primary and metastatic tumors. Here, we show that the mRNA-binding protein insulin-like growth factor 3 is crucial for non-small cell lung cancer progression and metastasis. We construct an inhalable nanoliposome system to co-deliver osimertinib and DNA plasmid for gene knockdown. Upon inhalation, these nanoparticles efficiently penetrate pulmonary barriers and accumulate in lungs by mimicking natural lung surfactants. Within tumor cells, released osimertinib inhibits tumor growth, while the DNA triggers the production of engineered exosomes that can travel to the brain to suppress tumors. This strategy effectively inhibits both primary and metastatic tumors while enhancing antitumor immune responses. This work suggests that this inhalable nanomedicine offers a safe and versatile strategy for cancer therapy. |
| format | Article |
| id | doaj-art-1c1e477c92534524842fd2dbbfdbd7e9 |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-1c1e477c92534524842fd2dbbfdbd7e92025-08-20T03:10:14ZengNature PortfolioNature Communications2041-17232025-04-0116111910.1038/s41467-025-58312-5Inhalable liposomal delivery of osimertinib and DNA for treating primary and metastasis lung cancerXianglei Fu0Yanbin Shi1Hang Wu2Yankun Zhang3Yingying Liu4Xiaoyu Wan5Xiangqin Chen6Jiamin Zhou7Shengnan Qiu8Xiaogang Zhao9Zhongxian Tian10Lian Li11Hengchang Zang12Guimei Lin13NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong UniversitySchool of Mechanical and Automotive Engineering, Qilu University of Technology (Shandong Academy of Sciences)Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical CollegeNMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong UniversityNMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong UniversityNMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong UniversityNMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong UniversityNMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong UniversityNMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong UniversityDepartment of Thoracic Surgery, The Second Hospital of Shandong UniversityDepartment of Thoracic Surgery, The Second Hospital of Shandong UniversityNMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong UniversityNMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong UniversityNMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong UniversityAbstract Lung cancer remains one of the most common malignancies, and its brain metastases significantly worsen the prognosis for patients. Current treatments for lung cancer face many challenges, including poor drug accumulation and the inability to simultaneously control primary and metastatic tumors. Here, we show that the mRNA-binding protein insulin-like growth factor 3 is crucial for non-small cell lung cancer progression and metastasis. We construct an inhalable nanoliposome system to co-deliver osimertinib and DNA plasmid for gene knockdown. Upon inhalation, these nanoparticles efficiently penetrate pulmonary barriers and accumulate in lungs by mimicking natural lung surfactants. Within tumor cells, released osimertinib inhibits tumor growth, while the DNA triggers the production of engineered exosomes that can travel to the brain to suppress tumors. This strategy effectively inhibits both primary and metastatic tumors while enhancing antitumor immune responses. This work suggests that this inhalable nanomedicine offers a safe and versatile strategy for cancer therapy.https://doi.org/10.1038/s41467-025-58312-5 |
| spellingShingle | Xianglei Fu Yanbin Shi Hang Wu Yankun Zhang Yingying Liu Xiaoyu Wan Xiangqin Chen Jiamin Zhou Shengnan Qiu Xiaogang Zhao Zhongxian Tian Lian Li Hengchang Zang Guimei Lin Inhalable liposomal delivery of osimertinib and DNA for treating primary and metastasis lung cancer Nature Communications |
| title | Inhalable liposomal delivery of osimertinib and DNA for treating primary and metastasis lung cancer |
| title_full | Inhalable liposomal delivery of osimertinib and DNA for treating primary and metastasis lung cancer |
| title_fullStr | Inhalable liposomal delivery of osimertinib and DNA for treating primary and metastasis lung cancer |
| title_full_unstemmed | Inhalable liposomal delivery of osimertinib and DNA for treating primary and metastasis lung cancer |
| title_short | Inhalable liposomal delivery of osimertinib and DNA for treating primary and metastasis lung cancer |
| title_sort | inhalable liposomal delivery of osimertinib and dna for treating primary and metastasis lung cancer |
| url | https://doi.org/10.1038/s41467-025-58312-5 |
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