A gut instinct for childhood leukemia prevention: microbiome-targeting recommendations aimed at parents and caregivers
Childhood leukemia accounts for 30% of all pediatric cancer cases with acute lymphoblastic leukemia (ALL) being the most common subtype. Involvement of the gut microbiome in ALL development has recently garnered interest due to an increasing recognition of the key contribution the microbiome plays i...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1445113/full |
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| author | Ersen Kameri Ersen Kameri Ersen Kameri Vera Helena Jepsen Pawel Stachura Pawel Stachura Nadine Rüchel Rigveda Bhave Leticia Benitez Fatima Crispi Eduard Gratacos Nico Dragano Stefan Janssen Arndt Borkhardt Arndt Borkhardt Aleksandra Pandyra Aleksandra Pandyra Aleksandra Pandyra Gesine Kögler Gesine Kögler Ute Fischer Ute Fischer Ute Fischer |
| author_facet | Ersen Kameri Ersen Kameri Ersen Kameri Vera Helena Jepsen Pawel Stachura Pawel Stachura Nadine Rüchel Rigveda Bhave Leticia Benitez Fatima Crispi Eduard Gratacos Nico Dragano Stefan Janssen Arndt Borkhardt Arndt Borkhardt Aleksandra Pandyra Aleksandra Pandyra Aleksandra Pandyra Gesine Kögler Gesine Kögler Ute Fischer Ute Fischer Ute Fischer |
| author_sort | Ersen Kameri |
| collection | DOAJ |
| description | Childhood leukemia accounts for 30% of all pediatric cancer cases with acute lymphoblastic leukemia (ALL) being the most common subtype. Involvement of the gut microbiome in ALL development has recently garnered interest due to an increasing recognition of the key contribution the microbiome plays in maintaining the immune system's homeostatic balance. Commensal gut microbiota provide a first line of defense against different pathogens and gut microbiome immaturity has been implicated in ALL pathogenesis. Several environmental factors such as nutrition, mode of delivery, breastfeeding and, early social or livestock contacts are known to alter the composition of the gut microbiota. Variations in these factors influence the risk of childhood leukemia onset. This review aims to elucidate the risk factors influencing microbial composition in the context of childhood ALL. The link between gut microbiome diversity and childhood ALL offers the opportunity to develop risk-reducing strategies that can be communicated to a broad target population of (future) parents and caregivers for childhood leukemia prevention. Here, we summarize evidence on how promoting a diverse gut microbiome in newborns through simple measures such as increasing social contacts early in life may decrease the risk of developing ALL in these children later on. |
| format | Article |
| id | doaj-art-1c1e001fe03f44509c826e9a17e8098b |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-1c1e001fe03f44509c826e9a17e8098b2025-01-13T05:10:17ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-01-011210.3389/fpubh.2024.14451131445113A gut instinct for childhood leukemia prevention: microbiome-targeting recommendations aimed at parents and caregiversErsen Kameri0Ersen Kameri1Ersen Kameri2Vera Helena Jepsen3Pawel Stachura4Pawel Stachura5Nadine Rüchel6Rigveda Bhave7Leticia Benitez8Fatima Crispi9Eduard Gratacos10Nico Dragano11Stefan Janssen12Arndt Borkhardt13Arndt Borkhardt14Aleksandra Pandyra15Aleksandra Pandyra16Aleksandra Pandyra17Gesine Kögler18Gesine Kögler19Ute Fischer20Ute Fischer21Ute Fischer22Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Centre of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, GermanyCancer Prevention-Graduate School, German Cancer Research Center (DKFZ), Heidelberg, GermanyInstitute of Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine-University, Düsseldorf, GermanyDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Centre of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, GermanyDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Centre of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, GermanyDepartment of Molecular Medicine II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, GermanyDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Centre of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, GermanyInstitute of Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine-University, Düsseldorf, GermanyBCNatal, Fetal Medicine Research Center (Hospital Clinic and Hospital Sant Joan de Déu), University of Barcelona, Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainBCNatal, Fetal Medicine Research Center (Hospital Clinic and Hospital Sant Joan de Déu), University of Barcelona, Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainBCNatal, Fetal Medicine Research Center (Hospital Clinic and Hospital Sant Joan de Déu), University of Barcelona, Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainInstitute of Medical Sociology, Centre for Health and Society, Medical Faculty, Heinrich-Heine-University, Düsseldorf, GermanyAlgorithmic Bioinformatics, Department of Biology and Chemistry, Justus Liebig University Gießen, Gießen, GermanyDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Centre of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, GermanyGerman Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, GermanyDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Centre of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, GermanyInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany0German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Bonn, GermanyCancer Prevention-Graduate School, German Cancer Research Center (DKFZ), Heidelberg, GermanyInstitute of Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine-University, Düsseldorf, GermanyDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Centre of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, GermanyCancer Prevention-Graduate School, German Cancer Research Center (DKFZ), Heidelberg, GermanyGerman Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, GermanyChildhood leukemia accounts for 30% of all pediatric cancer cases with acute lymphoblastic leukemia (ALL) being the most common subtype. Involvement of the gut microbiome in ALL development has recently garnered interest due to an increasing recognition of the key contribution the microbiome plays in maintaining the immune system's homeostatic balance. Commensal gut microbiota provide a first line of defense against different pathogens and gut microbiome immaturity has been implicated in ALL pathogenesis. Several environmental factors such as nutrition, mode of delivery, breastfeeding and, early social or livestock contacts are known to alter the composition of the gut microbiota. Variations in these factors influence the risk of childhood leukemia onset. This review aims to elucidate the risk factors influencing microbial composition in the context of childhood ALL. The link between gut microbiome diversity and childhood ALL offers the opportunity to develop risk-reducing strategies that can be communicated to a broad target population of (future) parents and caregivers for childhood leukemia prevention. Here, we summarize evidence on how promoting a diverse gut microbiome in newborns through simple measures such as increasing social contacts early in life may decrease the risk of developing ALL in these children later on.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1445113/fullchildhood leukemiarisk factorsgut microbiomepreventionrecommendationspublic health |
| spellingShingle | Ersen Kameri Ersen Kameri Ersen Kameri Vera Helena Jepsen Pawel Stachura Pawel Stachura Nadine Rüchel Rigveda Bhave Leticia Benitez Fatima Crispi Eduard Gratacos Nico Dragano Stefan Janssen Arndt Borkhardt Arndt Borkhardt Aleksandra Pandyra Aleksandra Pandyra Aleksandra Pandyra Gesine Kögler Gesine Kögler Ute Fischer Ute Fischer Ute Fischer A gut instinct for childhood leukemia prevention: microbiome-targeting recommendations aimed at parents and caregivers Frontiers in Public Health childhood leukemia risk factors gut microbiome prevention recommendations public health |
| title | A gut instinct for childhood leukemia prevention: microbiome-targeting recommendations aimed at parents and caregivers |
| title_full | A gut instinct for childhood leukemia prevention: microbiome-targeting recommendations aimed at parents and caregivers |
| title_fullStr | A gut instinct for childhood leukemia prevention: microbiome-targeting recommendations aimed at parents and caregivers |
| title_full_unstemmed | A gut instinct for childhood leukemia prevention: microbiome-targeting recommendations aimed at parents and caregivers |
| title_short | A gut instinct for childhood leukemia prevention: microbiome-targeting recommendations aimed at parents and caregivers |
| title_sort | gut instinct for childhood leukemia prevention microbiome targeting recommendations aimed at parents and caregivers |
| topic | childhood leukemia risk factors gut microbiome prevention recommendations public health |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1445113/full |
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