Two-component vasopressor therapy for septic shock
The objective: to investigate the efficacy and safety of terlipressin when it is used as an additional vasopressor in septic shock.Subjects: A single-center, observational, retrospective-prospective study of the efficacy and safety of combined therapy of septic shock with norepinephrine and terlipre...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2021-03-01
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| Series: | Вестник анестезиологии и реаниматологии |
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| Online Access: | https://www.vair-journal.com/jour/article/view/498 |
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| author | A. A. Kochkin V. V. Likhvantsev К. К. Kadantseva |
| author_facet | A. A. Kochkin V. V. Likhvantsev К. К. Kadantseva |
| author_sort | A. A. Kochkin |
| collection | DOAJ |
| description | The objective: to investigate the efficacy and safety of terlipressin when it is used as an additional vasopressor in septic shock.Subjects: A single-center, observational, retrospective-prospective study of the efficacy and safety of combined therapy of septic shock with norepinephrine and terlipressin versus monotherapy with norepinephrine was conducted.Results. The use of terlipressin made it possible to reduce the average daily need for noradrenaline in patients with septic shock from 0.68 μg · kg-1 · min-1 in the control group to 0.55 μg · kg-1 · min-1 in the study group (p = 0.015) and reduce the duration of vasopressor support from 8 days [6.0-11.0] to 6 days [5.0-8.0] in the study group (p = 0.023). The use of terlipressin did not reduce the need for mechanical ventilation, but it did reduce the duration of ventilation. The number of days free from mechanical ventilation in patients in the control group was 6.0 [1.0-18.0], in the study group - 16.0 [2.0-22.0], (p = 0.039).Conclusion. The use of terlipressin as a supplement to norepinephrine is an effective and relatively safe treatment for hypotension in refractory septic shock. |
| format | Article |
| id | doaj-art-1c16897e85b84ac3ad80a7575db20fbc |
| institution | Kabale University |
| issn | 2078-5658 2541-8653 |
| language | Russian |
| publishDate | 2021-03-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Вестник анестезиологии и реаниматологии |
| spelling | doaj-art-1c16897e85b84ac3ad80a7575db20fbc2025-08-20T03:42:48ZrusNew Terra Publishing HouseВестник анестезиологии и реаниматологии2078-56582541-86532021-03-01181576410.21292/2078-5658-2021-18-1-57-64428Two-component vasopressor therapy for septic shockA. A. Kochkin0V. V. Likhvantsev1К. К. Kadantseva2M.F. Vladimirsky Moscow Regional Research Clinical InstituteM. F. Vladimirsky Moscow Regional Research Clinical Institute; V. A. Negovsky Scientific Research Institute of General ReanimatologyV. A. Negovsky Scientific Research Institute of General Reanimatology; A. S. Loginov Moscow Clinical Scientific CenterThe objective: to investigate the efficacy and safety of terlipressin when it is used as an additional vasopressor in septic shock.Subjects: A single-center, observational, retrospective-prospective study of the efficacy and safety of combined therapy of septic shock with norepinephrine and terlipressin versus monotherapy with norepinephrine was conducted.Results. The use of terlipressin made it possible to reduce the average daily need for noradrenaline in patients with septic shock from 0.68 μg · kg-1 · min-1 in the control group to 0.55 μg · kg-1 · min-1 in the study group (p = 0.015) and reduce the duration of vasopressor support from 8 days [6.0-11.0] to 6 days [5.0-8.0] in the study group (p = 0.023). The use of terlipressin did not reduce the need for mechanical ventilation, but it did reduce the duration of ventilation. The number of days free from mechanical ventilation in patients in the control group was 6.0 [1.0-18.0], in the study group - 16.0 [2.0-22.0], (p = 0.039).Conclusion. The use of terlipressin as a supplement to norepinephrine is an effective and relatively safe treatment for hypotension in refractory septic shock.https://www.vair-journal.com/jour/article/view/498sepsisseptic shockvasopressor supportterlipressin |
| spellingShingle | A. A. Kochkin V. V. Likhvantsev К. К. Kadantseva Two-component vasopressor therapy for septic shock Вестник анестезиологии и реаниматологии sepsis septic shock vasopressor support terlipressin |
| title | Two-component vasopressor therapy for septic shock |
| title_full | Two-component vasopressor therapy for septic shock |
| title_fullStr | Two-component vasopressor therapy for septic shock |
| title_full_unstemmed | Two-component vasopressor therapy for septic shock |
| title_short | Two-component vasopressor therapy for septic shock |
| title_sort | two component vasopressor therapy for septic shock |
| topic | sepsis septic shock vasopressor support terlipressin |
| url | https://www.vair-journal.com/jour/article/view/498 |
| work_keys_str_mv | AT aakochkin twocomponentvasopressortherapyforsepticshock AT vvlikhvantsev twocomponentvasopressortherapyforsepticshock AT kkkadantseva twocomponentvasopressortherapyforsepticshock |