Atractylenolide I prevents acute liver failure in mouse by regulating M1 macrophage polarization

Atractylenolide I prevents acute liver failure in mouse by regulating M1 macrophage polarization

Abstract Acute liver failure (ALF) is a life-threatening clinical syndrome with a substantial risk of mortality. A murine model of lipopolysaccharide (LPS)- and D-galactosamine (D-GalN)-induced ALF is widely used to investigate the underlying mechanisms and potential therapeutic drugs for human live...

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Bibliographic Details
Main Authors: Hui Zhang, Min Gao, Haiyan Wang, Junfeng Zhang, Lin Wang, Guanjun Dong, Qun Ma, Chunxia Li, Jun Dai, Zhihua Li, Fenglian Yan, Huabao Xiong
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Acute liver failure
Atractylenolide I
M1 macrophage polarization
Inflammation
Oxidative stress
Online Access:https://doi.org/10.1038/s41598-025-86977-x
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