Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial
Aim. Type 2 diabetes increases the risk of cognitive decline which adversely impacts self-management of the disease. Evidence also supports a relationship between low serum 25(OH)D levels and poor cognition. The purpose of this trial was to assess vitamin D supplementation on cognitive executive fun...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2019/5696391 |
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| _version_ | 1850236924560670720 |
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| author | Mary A. Byrn William Adams Sue Penckofer Mary Ann Emanuele |
| author_facet | Mary A. Byrn William Adams Sue Penckofer Mary Ann Emanuele |
| author_sort | Mary A. Byrn |
| collection | DOAJ |
| description | Aim. Type 2 diabetes increases the risk of cognitive decline which adversely impacts self-management of the disease. Evidence also supports a relationship between low serum 25(OH)D levels and poor cognition. The purpose of this trial was to assess vitamin D supplementation on cognitive executive functioning in persons living with type 2 diabetes. Methods. This was a double-blinded RCT where participants were randomized to receive either weekly vitamin D3 supplementation (50,000 IUs) or a matching comparator (5,000 IUs) for three months. The primary outcome was a battery of neuropsychological tests. Serum 25(OH)D was measured by liquid chromatography/tandem mass spectrometry. Repeated assessments of cognitive measures were collected over 12 weeks using alternative testing forms to minimize practice effects. Results. Thirty participants were randomized to either the low-dose allocation (n=15) or the high-dose allocation (n=15). Most participants were female (83%) and identified as Black (57%). For all cognition measures, there was no statistically significant finding between participants who received high-dose vitamin D supplementation and those who received low-dose supplementation. However, when assessing cognitive function in both groups over time, minimal improvement on the Symbol-Digits, the Stroop Interference Test, and the Trail Making Test Part B was observed. Conclusions. To our knowledge, this is the first randomized control trial to examine the effects of vitamin D supplementation on cognitive function in people with type 2 diabetes. However, no significant differences in cognitive outcomes between participants who received high-dose therapy and those who received low dose were found. |
| format | Article |
| id | doaj-art-1c0907a20e2243ecb298611cb2ab04fe |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-1c0907a20e2243ecb298611cb2ab04fe2025-08-20T02:01:51ZengWileyJournal of Diabetes Research2314-67452314-67532019-01-01201910.1155/2019/56963915696391Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control TrialMary A. Byrn0William Adams1Sue Penckofer2Mary Ann Emanuele3Loyola University Chicago, Chicago, IL, USALoyola University Chicago, Chicago, IL, USALoyola University Chicago, Chicago, IL, USALoyola University Chicago, Chicago, IL, USAAim. Type 2 diabetes increases the risk of cognitive decline which adversely impacts self-management of the disease. Evidence also supports a relationship between low serum 25(OH)D levels and poor cognition. The purpose of this trial was to assess vitamin D supplementation on cognitive executive functioning in persons living with type 2 diabetes. Methods. This was a double-blinded RCT where participants were randomized to receive either weekly vitamin D3 supplementation (50,000 IUs) or a matching comparator (5,000 IUs) for three months. The primary outcome was a battery of neuropsychological tests. Serum 25(OH)D was measured by liquid chromatography/tandem mass spectrometry. Repeated assessments of cognitive measures were collected over 12 weeks using alternative testing forms to minimize practice effects. Results. Thirty participants were randomized to either the low-dose allocation (n=15) or the high-dose allocation (n=15). Most participants were female (83%) and identified as Black (57%). For all cognition measures, there was no statistically significant finding between participants who received high-dose vitamin D supplementation and those who received low-dose supplementation. However, when assessing cognitive function in both groups over time, minimal improvement on the Symbol-Digits, the Stroop Interference Test, and the Trail Making Test Part B was observed. Conclusions. To our knowledge, this is the first randomized control trial to examine the effects of vitamin D supplementation on cognitive function in people with type 2 diabetes. However, no significant differences in cognitive outcomes between participants who received high-dose therapy and those who received low dose were found.http://dx.doi.org/10.1155/2019/5696391 |
| spellingShingle | Mary A. Byrn William Adams Sue Penckofer Mary Ann Emanuele Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial Journal of Diabetes Research |
| title | Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial |
| title_full | Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial |
| title_fullStr | Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial |
| title_full_unstemmed | Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial |
| title_short | Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial |
| title_sort | vitamin d supplementation and cognition in people with type 2 diabetes a randomized control trial |
| url | http://dx.doi.org/10.1155/2019/5696391 |
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