Complex of Cyclosporins Produced by Tolypocladium inflatum Isolated from Soil Sample of Buryatiya
A micromycete culture was isolated from a soil sample of Buryatiya and identified as Tolypocladium inflatum No. 2. The culture was shown to produce a complex of cyclosporins ofunusual component structure: the content of cyclosporin A (55—60%) was the same as that in the substances produced by the ma...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/257 |
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| author | M. V. Bibikova T. A. Darkhanova I. A. Spiridonova A. N. Danilenko A. V. Katlinsky |
| author_facet | M. V. Bibikova T. A. Darkhanova I. A. Spiridonova A. N. Danilenko A. V. Katlinsky |
| author_sort | M. V. Bibikova |
| collection | DOAJ |
| description | A micromycete culture was isolated from a soil sample of Buryatiya and identified as Tolypocladium inflatum No. 2. The culture was shown to produce a complex of cyclosporins ofunusual component structure: the content of cyclosporin A (55—60%) was the same as that in the substances produced by the majority of the described cultures, the content of cyclosporin B was much higher (about 40%) and the content of cyclosporin C was relatively low (about 3%). An appreciable content of cyclosporin (Leu4)Cs (3%) proved to be of interest. |
| format | Article |
| id | doaj-art-1c0400a0f2824a4990f141e59e3ea281 |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-1c0400a0f2824a4990f141e59e3ea2812025-08-20T03:20:37ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01549-1069256Complex of Cyclosporins Produced by Tolypocladium inflatum Isolated from Soil Sample of BuryatiyaM. V. Bibikova0T. A. Darkhanova1I. A. Spiridonova2A. N. Danilenko3A. V. Katlinsky4National Research Centre of Antibiotics, Moscow M. Emanuel Institute of Biochemical Physics, MoscowNational Research Centre of Antibiotics, Moscow M. Emanuel Institute of Biochemical Physics, MoscowNational Research Centre of Antibiotics, Moscow M. Emanuel Institute of Biochemical Physics, MoscowI. M. Sechenov Moscow Medical AcademyI. M. Sechenov Moscow Medical AcademyA micromycete culture was isolated from a soil sample of Buryatiya and identified as Tolypocladium inflatum No. 2. The culture was shown to produce a complex of cyclosporins ofunusual component structure: the content of cyclosporin A (55—60%) was the same as that in the substances produced by the majority of the described cultures, the content of cyclosporin B was much higher (about 40%) and the content of cyclosporin C was relatively low (about 3%). An appreciable content of cyclosporin (Leu4)Cs (3%) proved to be of interest.https://www.antibiotics-chemotherapy.ru/jour/article/view/257tolypocladium inflatumcyclosporinstolypocladium inflatum |
| spellingShingle | M. V. Bibikova T. A. Darkhanova I. A. Spiridonova A. N. Danilenko A. V. Katlinsky Complex of Cyclosporins Produced by Tolypocladium inflatum Isolated from Soil Sample of Buryatiya Антибиотики и Химиотерапия tolypocladium inflatum cyclosporins tolypocladium inflatum |
| title | Complex of Cyclosporins Produced by Tolypocladium inflatum Isolated from Soil Sample of Buryatiya |
| title_full | Complex of Cyclosporins Produced by Tolypocladium inflatum Isolated from Soil Sample of Buryatiya |
| title_fullStr | Complex of Cyclosporins Produced by Tolypocladium inflatum Isolated from Soil Sample of Buryatiya |
| title_full_unstemmed | Complex of Cyclosporins Produced by Tolypocladium inflatum Isolated from Soil Sample of Buryatiya |
| title_short | Complex of Cyclosporins Produced by Tolypocladium inflatum Isolated from Soil Sample of Buryatiya |
| title_sort | complex of cyclosporins produced by tolypocladium inflatum isolated from soil sample of buryatiya |
| topic | tolypocladium inflatum cyclosporins tolypocladium inflatum |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/257 |
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