Integrative analysis of KEAP1/NFE2L2 alterations across 3600+ tumors reveals an NRF2 expression signature as a prognostic biomarker in cancer

Integrative analysis of KEAP1/NFE2L2 alterations across 3600+ tumors reveals an NRF2 expression signature as a prognostic biomarker in cancer

Abstract Non-small cell lung cancer (NSCLC) remains a formidable global health challenge, with heterogeneous molecular characteristics influencing prognosis and treatment response. We present a novel computational framework named ASTUTE (Association of SomaTic mUtaTions to gene Expression profiles),...

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Bibliographic Details
Main Authors:	Valentina Crippa, Nicoletta Cordani, Alberto Maria Villa, Federica Malighetti, Matteo Villa, Luca Sala, Andrea Aroldi, Rocco Piazza, Diego Cortinovis, Luca Mologni, Daniele Ramazzotti
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Series:	npj Precision Oncology
Online Access:	https://doi.org/10.1038/s41698-025-01088-0
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