Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural Lipomatosis
Introduction. Spinal neurosarcoidosis is a rare disease that can manifest as myelopathy, radiculopathy, or cauda equine syndrome. Spinal epidural lipomatosis is also a rare condition resulting from overgrowth of epidural fat tissue causing compressive myelopathy. To our knowledge, there are no repor...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/5952724 |
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| author | Nesreen Jaafar Maria Khoueiry Samia J. Khoury Achraf Makki |
| author_facet | Nesreen Jaafar Maria Khoueiry Samia J. Khoury Achraf Makki |
| author_sort | Nesreen Jaafar |
| collection | DOAJ |
| description | Introduction. Spinal neurosarcoidosis is a rare disease that can manifest as myelopathy, radiculopathy, or cauda equine syndrome. Spinal epidural lipomatosis is also a rare condition resulting from overgrowth of epidural fat tissue causing compressive myelopathy. To our knowledge, there are no reports linking epidural lipomatosis and spinal neurosarcoidosis. Case Report. We describe a case of progressive myelitis in the presence of concomitant spinal neurosarcoidosis and epidural lipomatosis which was a challenging diagnosis with complete response to treatment after addressing both diseases. Both etiologies are inflammatory in nature and share similar expression of inflammatory factors such as TNF-α and IL-1β. Conclusion. The common inflammatory process involved in these two diseases might explain a pathophysiological interconnection between both diseases that may underlie their concomitant development in our patient. If these two diseases are interconnected, in their pathophysiological mechanism remains a hypothesis that will need further investigation. |
| format | Article |
| id | doaj-art-1c021c00b8f647d28d2b55b150f20259 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-1c021c00b8f647d28d2b55b150f202592025-02-03T06:07:40ZengWileyCase Reports in Neurological Medicine2090-66682090-66762021-01-01202110.1155/2021/59527245952724Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural LipomatosisNesreen Jaafar0Maria Khoueiry1Samia J. Khoury2Achraf Makki3Department of Neurology, American University of Beirut Medical Center, Beirut, LebanonDepartment of Neurology, American University of Beirut Medical Center, Beirut, LebanonNehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, LebanonDepartment of Neurology, American University of Beirut Medical Center, Beirut, LebanonIntroduction. Spinal neurosarcoidosis is a rare disease that can manifest as myelopathy, radiculopathy, or cauda equine syndrome. Spinal epidural lipomatosis is also a rare condition resulting from overgrowth of epidural fat tissue causing compressive myelopathy. To our knowledge, there are no reports linking epidural lipomatosis and spinal neurosarcoidosis. Case Report. We describe a case of progressive myelitis in the presence of concomitant spinal neurosarcoidosis and epidural lipomatosis which was a challenging diagnosis with complete response to treatment after addressing both diseases. Both etiologies are inflammatory in nature and share similar expression of inflammatory factors such as TNF-α and IL-1β. Conclusion. The common inflammatory process involved in these two diseases might explain a pathophysiological interconnection between both diseases that may underlie their concomitant development in our patient. If these two diseases are interconnected, in their pathophysiological mechanism remains a hypothesis that will need further investigation.http://dx.doi.org/10.1155/2021/5952724 |
| spellingShingle | Nesreen Jaafar Maria Khoueiry Samia J. Khoury Achraf Makki Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural Lipomatosis Case Reports in Neurological Medicine |
| title | Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural Lipomatosis |
| title_full | Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural Lipomatosis |
| title_fullStr | Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural Lipomatosis |
| title_full_unstemmed | Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural Lipomatosis |
| title_short | Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural Lipomatosis |
| title_sort | rare case of spinal neurosarcoidosis with concomitant epidural lipomatosis |
| url | http://dx.doi.org/10.1155/2021/5952724 |
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