Process Improvement for the Continuous Synthesis of <i>N</i>-Benzylhydroxylamine Hydrochloride
<i>N</i>-Benzylhydroxylamine hydrochloride serves as a critical intermediate in organic synthesis, yet traditional synthesis methods often face significant safety risks and high production costs. In this work, we developed a continuous synthesis process for <i>N</i>-benzylhyd...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Chemistry |
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| Online Access: | https://www.mdpi.com/2624-8549/7/3/70 |
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| author | Xiaoguang Chen Ke Chen Guoxian Cai Haoyue Xiang Kai Chen Hua Yang |
| author_facet | Xiaoguang Chen Ke Chen Guoxian Cai Haoyue Xiang Kai Chen Hua Yang |
| author_sort | Xiaoguang Chen |
| collection | DOAJ |
| description | <i>N</i>-Benzylhydroxylamine hydrochloride serves as a critical intermediate in organic synthesis, yet traditional synthesis methods often face significant safety risks and high production costs. In this work, we developed a continuous synthesis process for <i>N</i>-benzylhydroxylamine hydrochloride, achieving an overall yield of 75% under mild and safe reaction conditions. Additionally, the implementation of solvent recovery and the recycling of hydroxylamine hydrochloride reduced the production cost to approximately $10 per kilogram. These advancements underscore the economic and practical viability of this method for large-scale industrial applications. |
| format | Article |
| id | doaj-art-1bfead050a5a4e1497b54a37f808fa00 |
| institution | OA Journals |
| issn | 2624-8549 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemistry |
| spelling | doaj-art-1bfead050a5a4e1497b54a37f808fa002025-08-20T02:24:37ZengMDPI AGChemistry2624-85492025-04-01737010.3390/chemistry7030070Process Improvement for the Continuous Synthesis of <i>N</i>-Benzylhydroxylamine HydrochlorideXiaoguang Chen0Ke Chen1Guoxian Cai2Haoyue Xiang3Kai Chen4Hua Yang5College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, ChinaHunan Warrant Chiral Pharmaceutical Co., Ltd., Changsha 410204, ChinaHunan Warrant Chiral Pharmaceutical Co., Ltd., Changsha 410204, ChinaCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410083, ChinaCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410083, ChinaCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China<i>N</i>-Benzylhydroxylamine hydrochloride serves as a critical intermediate in organic synthesis, yet traditional synthesis methods often face significant safety risks and high production costs. In this work, we developed a continuous synthesis process for <i>N</i>-benzylhydroxylamine hydrochloride, achieving an overall yield of 75% under mild and safe reaction conditions. Additionally, the implementation of solvent recovery and the recycling of hydroxylamine hydrochloride reduced the production cost to approximately $10 per kilogram. These advancements underscore the economic and practical viability of this method for large-scale industrial applications.https://www.mdpi.com/2624-8549/7/3/70<i>N</i>-benzylhydroxylamine hydrochloridecontinuous synthesisflow chemistry |
| spellingShingle | Xiaoguang Chen Ke Chen Guoxian Cai Haoyue Xiang Kai Chen Hua Yang Process Improvement for the Continuous Synthesis of <i>N</i>-Benzylhydroxylamine Hydrochloride Chemistry <i>N</i>-benzylhydroxylamine hydrochloride continuous synthesis flow chemistry |
| title | Process Improvement for the Continuous Synthesis of <i>N</i>-Benzylhydroxylamine Hydrochloride |
| title_full | Process Improvement for the Continuous Synthesis of <i>N</i>-Benzylhydroxylamine Hydrochloride |
| title_fullStr | Process Improvement for the Continuous Synthesis of <i>N</i>-Benzylhydroxylamine Hydrochloride |
| title_full_unstemmed | Process Improvement for the Continuous Synthesis of <i>N</i>-Benzylhydroxylamine Hydrochloride |
| title_short | Process Improvement for the Continuous Synthesis of <i>N</i>-Benzylhydroxylamine Hydrochloride |
| title_sort | process improvement for the continuous synthesis of i n i benzylhydroxylamine hydrochloride |
| topic | <i>N</i>-benzylhydroxylamine hydrochloride continuous synthesis flow chemistry |
| url | https://www.mdpi.com/2624-8549/7/3/70 |
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