Spatial Analysis of Anthropogenic Landscape Disturbance and Buruli Ulcer Disease in Benin.
<h4>Background</h4>Land use and land cover (LULC) change is one anthropogenic disturbance linked to infectious disease emergence. Current research has focused largely on wildlife and vector-borne zoonotic diseases, neglecting to investigate landscape disturbance and environmental bacteri...
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0004123 |
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| author | Lindsay P Campbell Andrew O Finley M Eric Benbow Jenni Gronseth Pamela Small Roch Christian Johnson Ghislain E Sopoh Richard M Merritt Heather Williamson Jiaguo Qi |
| author_facet | Lindsay P Campbell Andrew O Finley M Eric Benbow Jenni Gronseth Pamela Small Roch Christian Johnson Ghislain E Sopoh Richard M Merritt Heather Williamson Jiaguo Qi |
| author_sort | Lindsay P Campbell |
| collection | DOAJ |
| description | <h4>Background</h4>Land use and land cover (LULC) change is one anthropogenic disturbance linked to infectious disease emergence. Current research has focused largely on wildlife and vector-borne zoonotic diseases, neglecting to investigate landscape disturbance and environmental bacterial infections. One example is Buruli ulcer (BU) disease, a necrotizing skin disease caused by the environmental pathogen Mycobacterium ulcerans (MU). Empirical and anecdotal observations have linked BU incidence to landscape disturbance, but potential relationships have not been quantified as they relate to land cover configurations.<h4>Methodology/principal findings</h4>A landscape ecological approach utilizing Bayesian hierarchical models with spatial random effects was used to test study hypotheses that land cover configurations indicative of anthropogenic disturbance were related to Buruli ulcer (BU) disease in southern Benin, and that a spatial structure existed for drivers of BU case distribution in the region. A final objective was to generate a continuous, risk map across the study region. Results suggested that villages surrounded by naturally shaped, or undisturbed rather than disturbed, wetland patches at a distance within 1200 m were at a higher risk for BU, and study outcomes supported the hypothesis that a spatial structure exists for the drivers behind BU risk in the region. The risk surface corresponded to known BU endemicity in Benin and identified moderate risk areas within the boundary of Togo.<h4>Conclusions/significance</h4>This study was a first attempt to link land cover configurations representative of anthropogenic disturbances to BU prevalence. Study results identified several significant variables, including the presence of natural wetland areas, warranting future investigations into these factors at additional spatial and temporal scales. A major contribution of this study included the incorporation of a spatial modeling component that predicted BU rates to new locations without strong knowledge of environmental factors contributing to disease distribution. |
| format | Article |
| id | doaj-art-1bfdecb827d244beb07f396d328b047d |
| institution | OA Journals |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-1bfdecb827d244beb07f396d328b047d2025-08-20T02:33:47ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352015-01-01910e000412310.1371/journal.pntd.0004123Spatial Analysis of Anthropogenic Landscape Disturbance and Buruli Ulcer Disease in Benin.Lindsay P CampbellAndrew O FinleyM Eric BenbowJenni GronsethPamela SmallRoch Christian JohnsonGhislain E SopohRichard M MerrittHeather WilliamsonJiaguo Qi<h4>Background</h4>Land use and land cover (LULC) change is one anthropogenic disturbance linked to infectious disease emergence. Current research has focused largely on wildlife and vector-borne zoonotic diseases, neglecting to investigate landscape disturbance and environmental bacterial infections. One example is Buruli ulcer (BU) disease, a necrotizing skin disease caused by the environmental pathogen Mycobacterium ulcerans (MU). Empirical and anecdotal observations have linked BU incidence to landscape disturbance, but potential relationships have not been quantified as they relate to land cover configurations.<h4>Methodology/principal findings</h4>A landscape ecological approach utilizing Bayesian hierarchical models with spatial random effects was used to test study hypotheses that land cover configurations indicative of anthropogenic disturbance were related to Buruli ulcer (BU) disease in southern Benin, and that a spatial structure existed for drivers of BU case distribution in the region. A final objective was to generate a continuous, risk map across the study region. Results suggested that villages surrounded by naturally shaped, or undisturbed rather than disturbed, wetland patches at a distance within 1200 m were at a higher risk for BU, and study outcomes supported the hypothesis that a spatial structure exists for the drivers behind BU risk in the region. The risk surface corresponded to known BU endemicity in Benin and identified moderate risk areas within the boundary of Togo.<h4>Conclusions/significance</h4>This study was a first attempt to link land cover configurations representative of anthropogenic disturbances to BU prevalence. Study results identified several significant variables, including the presence of natural wetland areas, warranting future investigations into these factors at additional spatial and temporal scales. A major contribution of this study included the incorporation of a spatial modeling component that predicted BU rates to new locations without strong knowledge of environmental factors contributing to disease distribution.https://doi.org/10.1371/journal.pntd.0004123 |
| spellingShingle | Lindsay P Campbell Andrew O Finley M Eric Benbow Jenni Gronseth Pamela Small Roch Christian Johnson Ghislain E Sopoh Richard M Merritt Heather Williamson Jiaguo Qi Spatial Analysis of Anthropogenic Landscape Disturbance and Buruli Ulcer Disease in Benin. PLoS Neglected Tropical Diseases |
| title | Spatial Analysis of Anthropogenic Landscape Disturbance and Buruli Ulcer Disease in Benin. |
| title_full | Spatial Analysis of Anthropogenic Landscape Disturbance and Buruli Ulcer Disease in Benin. |
| title_fullStr | Spatial Analysis of Anthropogenic Landscape Disturbance and Buruli Ulcer Disease in Benin. |
| title_full_unstemmed | Spatial Analysis of Anthropogenic Landscape Disturbance and Buruli Ulcer Disease in Benin. |
| title_short | Spatial Analysis of Anthropogenic Landscape Disturbance and Buruli Ulcer Disease in Benin. |
| title_sort | spatial analysis of anthropogenic landscape disturbance and buruli ulcer disease in benin |
| url | https://doi.org/10.1371/journal.pntd.0004123 |
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