Comparative in Vitro Study on the Antimicrobial Efficacy of Endodontic Sealers Against Common Oral Pathogens
<b>Background/Objectives</b>: Microorganisms are the leading cause of infections in the root canal system, contributing to the failure of endodontic treatments. This in vitro study aimed to compare the antimicrobial effects of four different endodontic sealers: Endomethasone N (Septodont...
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2024-12-01
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| Series: | Dentistry Journal |
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| author | Csaba Dudás Zsuzsanna Bardocz-Veres Anita Iulia Gyulai Silvia Izabella Pop Melinda Székely Bernadette Kerekes-Máthé Mónika Kovács |
| author_facet | Csaba Dudás Zsuzsanna Bardocz-Veres Anita Iulia Gyulai Silvia Izabella Pop Melinda Székely Bernadette Kerekes-Máthé Mónika Kovács |
| author_sort | Csaba Dudás |
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| description | <b>Background/Objectives</b>: Microorganisms are the leading cause of infections in the root canal system, contributing to the failure of endodontic treatments. This in vitro study aimed to compare the antimicrobial effects of four different endodontic sealers: Endomethasone N (Septodont, Saint Maur-des-Fossés, France), Sealapex (Kerr Corporation, Orange, CA, USA), AH Plus Jet (Dentsply DeTrey GmbH, Konstanz, Germany), and MTA Fillapex (Angelus, Londrina, Brazil). <b>Methods</b>: The sealers were tested against common oral pathogens, including Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Candida albicans, and Streptococcus mutans, using the agar diffusion method. Inhibition zones were measured at 24, 48, and 72 h to assess antimicrobial efficacy. <b>Results</b>: The results showed that Endomethasone was the most effective sealer against all tested microorganisms, demonstrating consistent inhibition across all time intervals. MTA Fillapex also exhibited a significant antimicrobial effect, particularly against Streptococcus mutans, with its efficacy increasing over time. AH Plus Jet displayed limited effectiveness, showing significant results only against Staphylococcus aureus. <b>Conclusions:</b> Overall, this study confirms the superior antimicrobial performance of Endomethasone, while the other materials, particularly MTA Fillapex and Sealapex, also showed notable effects in experimental conditions. The antimicrobial activity of all materials, except AH Plus Jet, increased over the 72-h period. |
| format | Article |
| id | doaj-art-1bfac495dd5542c5ab21763f793c0c5b |
| institution | Kabale University |
| issn | 2304-6767 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj-art-1bfac495dd5542c5ab21763f793c0c5b2025-01-24T13:28:37ZengMDPI AGDentistry Journal2304-67672024-12-011311710.3390/dj13010017Comparative in Vitro Study on the Antimicrobial Efficacy of Endodontic Sealers Against Common Oral PathogensCsaba Dudás0Zsuzsanna Bardocz-Veres1Anita Iulia Gyulai2Silvia Izabella Pop3Melinda Székely4Bernadette Kerekes-Máthé5Mónika Kovács6Faculty of Dentistry, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Str., 540139 Târgu Mureș, RomaniaDepartment of Oral Rehabilitation and Occlusology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Str., 540139 Târgu Mureș, RomaniaFaculty of Dentistry, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Str., 540139 Târgu Mureș, RomaniaDepartment of Orthodontics, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Str., 540139 Târgu Mureș, RomaniaDepartment of Tooth and Dental Arch Morphology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Str., 540139 Târgu Mureș, RomaniaDepartment of Tooth and Dental Arch Morphology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Str., 540139 Târgu Mureș, RomaniaDepartment of Odontology and Oral Pathology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Str., 540139 Târgu Mureș, Romania<b>Background/Objectives</b>: Microorganisms are the leading cause of infections in the root canal system, contributing to the failure of endodontic treatments. This in vitro study aimed to compare the antimicrobial effects of four different endodontic sealers: Endomethasone N (Septodont, Saint Maur-des-Fossés, France), Sealapex (Kerr Corporation, Orange, CA, USA), AH Plus Jet (Dentsply DeTrey GmbH, Konstanz, Germany), and MTA Fillapex (Angelus, Londrina, Brazil). <b>Methods</b>: The sealers were tested against common oral pathogens, including Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Candida albicans, and Streptococcus mutans, using the agar diffusion method. Inhibition zones were measured at 24, 48, and 72 h to assess antimicrobial efficacy. <b>Results</b>: The results showed that Endomethasone was the most effective sealer against all tested microorganisms, demonstrating consistent inhibition across all time intervals. MTA Fillapex also exhibited a significant antimicrobial effect, particularly against Streptococcus mutans, with its efficacy increasing over time. AH Plus Jet displayed limited effectiveness, showing significant results only against Staphylococcus aureus. <b>Conclusions:</b> Overall, this study confirms the superior antimicrobial performance of Endomethasone, while the other materials, particularly MTA Fillapex and Sealapex, also showed notable effects in experimental conditions. The antimicrobial activity of all materials, except AH Plus Jet, increased over the 72-h period.https://www.mdpi.com/2304-6767/13/1/17endodontic sealerantimicrobialin vitro study |
| spellingShingle | Csaba Dudás Zsuzsanna Bardocz-Veres Anita Iulia Gyulai Silvia Izabella Pop Melinda Székely Bernadette Kerekes-Máthé Mónika Kovács Comparative in Vitro Study on the Antimicrobial Efficacy of Endodontic Sealers Against Common Oral Pathogens Dentistry Journal endodontic sealer antimicrobial in vitro study |
| title | Comparative in Vitro Study on the Antimicrobial Efficacy of Endodontic Sealers Against Common Oral Pathogens |
| title_full | Comparative in Vitro Study on the Antimicrobial Efficacy of Endodontic Sealers Against Common Oral Pathogens |
| title_fullStr | Comparative in Vitro Study on the Antimicrobial Efficacy of Endodontic Sealers Against Common Oral Pathogens |
| title_full_unstemmed | Comparative in Vitro Study on the Antimicrobial Efficacy of Endodontic Sealers Against Common Oral Pathogens |
| title_short | Comparative in Vitro Study on the Antimicrobial Efficacy of Endodontic Sealers Against Common Oral Pathogens |
| title_sort | comparative in vitro study on the antimicrobial efficacy of endodontic sealers against common oral pathogens |
| topic | endodontic sealer antimicrobial in vitro study |
| url | https://www.mdpi.com/2304-6767/13/1/17 |
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