Efficacy and safety of moxibustion for ulcerative colitis: protocol for a systematic review and meta-analysis
Introduction Ulcerative colitis (UC) is a global chronic inflammatory bowel disease, and the poor efficacy of currently available pharmacological regimens makes the management of UC a great challenge. Moxibustion has shown great potential in the management of UC. However, its effectiveness and safet...
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| Language: | English |
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BMJ Publishing Group
2024-03-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/3/e078878.full |
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| author | Wen Zhou Yanzhen Li Wenxiao Chen Bailing Deng Jianyu You |
| author_facet | Wen Zhou Yanzhen Li Wenxiao Chen Bailing Deng Jianyu You |
| author_sort | Wen Zhou |
| collection | DOAJ |
| description | Introduction Ulcerative colitis (UC) is a global chronic inflammatory bowel disease, and the poor efficacy of currently available pharmacological regimens makes the management of UC a great challenge. Moxibustion has shown great potential in the management of UC. However, its effectiveness and safety are still controversial. The purpose of this study is to synthesise the latest evidence regarding the clinical efficacy and safety of moxibustion for UC.Methods and analysis The Cochrane Library, PubMed, EMBASE, CNKI, Wanfang, VIP and SinoMed databases will be searched from inception to July 2023, to identify all randomised controlled trials with moxibustion for UC. The primary outcome will be clinical efficacy, as measured by validated scales. The serum inflammatory factor, colonoscopy results, quality of life, recurrence rate and adverse events will be the secondary outcomes. The Cochrane Risk of Bias 2.0 tool will be used to assess the methodological quality of each included trial. All data extraction will be carried out independently by two investigators. RevMan V.5.4 software will be used for data analysis and Cochran’s Q statistic and I2 test will be used to assess heterogeneity between studies. In addition, we will perform subgroup analyses, sensitivity analyses and publication bias if the available data are sufficient. The strength of evidence will be graded using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system.Ethics and dissemination Ethics approval is not required for this review. Our findings will be published in a peer-reviewed journal.PROSPERO registration number CRD42023425481. |
| format | Article |
| id | doaj-art-1bf98a896fa84d8c9dd44c8472cad06d |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-1bf98a896fa84d8c9dd44c8472cad06d2025-08-20T03:12:40ZengBMJ Publishing GroupBMJ Open2044-60552024-03-0114310.1136/bmjopen-2023-078878Efficacy and safety of moxibustion for ulcerative colitis: protocol for a systematic review and meta-analysisWen Zhou0Yanzhen Li1Wenxiao Chen2Bailing Deng3Jianyu You4Scientific Research Division, Nanchang Medical College, Nanchang, Jiangxi, ChinaSchool of Clinical Medicine, Nanchang Medical College, Nanchang, Jiangxi, ChinaScientific Research Division, Nanchang Medical College, Nanchang, Jiangxi, ChinaFormula-pattern Research Center, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, ChinaSchool of Acupuncture-Moxibustion and Tuina, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, ChinaIntroduction Ulcerative colitis (UC) is a global chronic inflammatory bowel disease, and the poor efficacy of currently available pharmacological regimens makes the management of UC a great challenge. Moxibustion has shown great potential in the management of UC. However, its effectiveness and safety are still controversial. The purpose of this study is to synthesise the latest evidence regarding the clinical efficacy and safety of moxibustion for UC.Methods and analysis The Cochrane Library, PubMed, EMBASE, CNKI, Wanfang, VIP and SinoMed databases will be searched from inception to July 2023, to identify all randomised controlled trials with moxibustion for UC. The primary outcome will be clinical efficacy, as measured by validated scales. The serum inflammatory factor, colonoscopy results, quality of life, recurrence rate and adverse events will be the secondary outcomes. The Cochrane Risk of Bias 2.0 tool will be used to assess the methodological quality of each included trial. All data extraction will be carried out independently by two investigators. RevMan V.5.4 software will be used for data analysis and Cochran’s Q statistic and I2 test will be used to assess heterogeneity between studies. In addition, we will perform subgroup analyses, sensitivity analyses and publication bias if the available data are sufficient. The strength of evidence will be graded using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system.Ethics and dissemination Ethics approval is not required for this review. Our findings will be published in a peer-reviewed journal.PROSPERO registration number CRD42023425481.https://bmjopen.bmj.com/content/14/3/e078878.full |
| spellingShingle | Wen Zhou Yanzhen Li Wenxiao Chen Bailing Deng Jianyu You Efficacy and safety of moxibustion for ulcerative colitis: protocol for a systematic review and meta-analysis BMJ Open |
| title | Efficacy and safety of moxibustion for ulcerative colitis: protocol for a systematic review and meta-analysis |
| title_full | Efficacy and safety of moxibustion for ulcerative colitis: protocol for a systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of moxibustion for ulcerative colitis: protocol for a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of moxibustion for ulcerative colitis: protocol for a systematic review and meta-analysis |
| title_short | Efficacy and safety of moxibustion for ulcerative colitis: protocol for a systematic review and meta-analysis |
| title_sort | efficacy and safety of moxibustion for ulcerative colitis protocol for a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/14/3/e078878.full |
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