Expedient Protocols for the Installation of Pyrimidine Based Privileged Templates on 2-Position of Pyrrolo[2,1-c][1,4]-benzodiazepine Nucleus Linked Through a p-phenoxyl Spacer

Exceedingly facile single step expedient protocols based on the versatility and reactivity of corresponding intermediates : [2-(dimethylaminomethylene) ketone] (5) and chalcone (6), derived from 2-(p-acetyl phenoxyl) substituted analogue of pyrrolo[2,1-c][1,4]-benzodiazepine (4), have been developed...

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Main Authors: Anshu Agarwal, Meenakshi Sharma, Meenakshi Agrawal, D. Kishore
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2012/629414
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author Anshu Agarwal
Meenakshi Sharma
Meenakshi Agrawal
D. Kishore
author_facet Anshu Agarwal
Meenakshi Sharma
Meenakshi Agrawal
D. Kishore
author_sort Anshu Agarwal
collection DOAJ
description Exceedingly facile single step expedient protocols based on the versatility and reactivity of corresponding intermediates : [2-(dimethylaminomethylene) ketone] (5) and chalcone (6), derived from 2-(p-acetyl phenoxyl) substituted analogue of pyrrolo[2,1-c][1,4]-benzodiazepine (4), have been developed to provide an easy installation of the pyrimidine based privileged templates at 2-position of pyrrolo[2,1-c][1,4]-benzodiazepine through a p-phenoxyl spacer, by utilizing the synthetic strategy depicted in schemes-1 and 2.
format Article
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language English
publishDate 2012-01-01
publisher Wiley
record_format Article
series E-Journal of Chemistry
spelling doaj-art-1bf5bc3d1e574d27b2d3b7104f5c1fa92025-02-03T05:48:20ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01931305131210.1155/2012/629414Expedient Protocols for the Installation of Pyrimidine Based Privileged Templates on 2-Position of Pyrrolo[2,1-c][1,4]-benzodiazepine Nucleus Linked Through a p-phenoxyl SpacerAnshu Agarwal0Meenakshi Sharma1Meenakshi Agrawal2D. Kishore3Department of Chemistry, Banasthali University, Banasthali (RAJ. 304022), IndiaDepartment of Chemistry, Banasthali University, Banasthali (RAJ. 304022), IndiaDepartment of Chemistry, Banasthali University, Banasthali (RAJ. 304022), IndiaDepartment of Chemistry, Banasthali University, Banasthali (RAJ. 304022), IndiaExceedingly facile single step expedient protocols based on the versatility and reactivity of corresponding intermediates : [2-(dimethylaminomethylene) ketone] (5) and chalcone (6), derived from 2-(p-acetyl phenoxyl) substituted analogue of pyrrolo[2,1-c][1,4]-benzodiazepine (4), have been developed to provide an easy installation of the pyrimidine based privileged templates at 2-position of pyrrolo[2,1-c][1,4]-benzodiazepine through a p-phenoxyl spacer, by utilizing the synthetic strategy depicted in schemes-1 and 2.http://dx.doi.org/10.1155/2012/629414
spellingShingle Anshu Agarwal
Meenakshi Sharma
Meenakshi Agrawal
D. Kishore
Expedient Protocols for the Installation of Pyrimidine Based Privileged Templates on 2-Position of Pyrrolo[2,1-c][1,4]-benzodiazepine Nucleus Linked Through a p-phenoxyl Spacer
E-Journal of Chemistry
title Expedient Protocols for the Installation of Pyrimidine Based Privileged Templates on 2-Position of Pyrrolo[2,1-c][1,4]-benzodiazepine Nucleus Linked Through a p-phenoxyl Spacer
title_full Expedient Protocols for the Installation of Pyrimidine Based Privileged Templates on 2-Position of Pyrrolo[2,1-c][1,4]-benzodiazepine Nucleus Linked Through a p-phenoxyl Spacer
title_fullStr Expedient Protocols for the Installation of Pyrimidine Based Privileged Templates on 2-Position of Pyrrolo[2,1-c][1,4]-benzodiazepine Nucleus Linked Through a p-phenoxyl Spacer
title_full_unstemmed Expedient Protocols for the Installation of Pyrimidine Based Privileged Templates on 2-Position of Pyrrolo[2,1-c][1,4]-benzodiazepine Nucleus Linked Through a p-phenoxyl Spacer
title_short Expedient Protocols for the Installation of Pyrimidine Based Privileged Templates on 2-Position of Pyrrolo[2,1-c][1,4]-benzodiazepine Nucleus Linked Through a p-phenoxyl Spacer
title_sort expedient protocols for the installation of pyrimidine based privileged templates on 2 position of pyrrolo 2 1 c 1 4 benzodiazepine nucleus linked through a p phenoxyl spacer
url http://dx.doi.org/10.1155/2012/629414
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