Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid
Here, we focused on a simple enzymatic epoxidation of alkenes using lipase and phenylacetic acid. The immobilised Candida antarctica lipase B, Novozym 435 was used to catalyse the formation of peroxy acid instantly from hydrogen peroxide (H2O2) and phenylacetic acid. The peroxy phenylacetic acid gen...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/756418 |
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| author | Emilia Abdulmalek Mahashanon Arumugam Hanis Nabillah Mizan Mohd. Basyaruddin Abdul Rahman Mahiran Basri Abu Bakar Salleh |
| author_facet | Emilia Abdulmalek Mahashanon Arumugam Hanis Nabillah Mizan Mohd. Basyaruddin Abdul Rahman Mahiran Basri Abu Bakar Salleh |
| author_sort | Emilia Abdulmalek |
| collection | DOAJ |
| description | Here, we focused on a simple enzymatic epoxidation of alkenes using lipase and phenylacetic acid. The immobilised Candida antarctica lipase B, Novozym 435 was used to catalyse the formation of peroxy acid instantly from hydrogen peroxide (H2O2) and phenylacetic acid. The peroxy phenylacetic acid generated was then utilised directly for in situ oxidation of alkenes. A variety of alkenes were oxidised with this system, resulting in 75–99% yield of the respective epoxides. On the other hand, the phenylacetic acid was recovered from the reaction media and reused for more epoxidation. Interestingly, the waste phenylacetic acid had the ability to be reused for epoxidation of the 1-nonene to 1-nonene oxide, giving an excellent yield of 90%. |
| format | Article |
| id | doaj-art-1bf138e1f1d0474d9865708e0c6eb5ef |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-1bf138e1f1d0474d9865708e0c6eb5ef2025-08-20T02:01:51ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/756418756418Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic AcidEmilia Abdulmalek0Mahashanon Arumugam1Hanis Nabillah Mizan2Mohd. Basyaruddin Abdul Rahman3Mahiran Basri4Abu Bakar Salleh5Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Biochemistry, Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaHere, we focused on a simple enzymatic epoxidation of alkenes using lipase and phenylacetic acid. The immobilised Candida antarctica lipase B, Novozym 435 was used to catalyse the formation of peroxy acid instantly from hydrogen peroxide (H2O2) and phenylacetic acid. The peroxy phenylacetic acid generated was then utilised directly for in situ oxidation of alkenes. A variety of alkenes were oxidised with this system, resulting in 75–99% yield of the respective epoxides. On the other hand, the phenylacetic acid was recovered from the reaction media and reused for more epoxidation. Interestingly, the waste phenylacetic acid had the ability to be reused for epoxidation of the 1-nonene to 1-nonene oxide, giving an excellent yield of 90%.http://dx.doi.org/10.1155/2014/756418 |
| spellingShingle | Emilia Abdulmalek Mahashanon Arumugam Hanis Nabillah Mizan Mohd. Basyaruddin Abdul Rahman Mahiran Basri Abu Bakar Salleh Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid The Scientific World Journal |
| title | Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
| title_full | Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
| title_fullStr | Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
| title_full_unstemmed | Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
| title_short | Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
| title_sort | chemoenzymatic epoxidation of alkenes and reusability study of the phenylacetic acid |
| url | http://dx.doi.org/10.1155/2014/756418 |
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